Evidence map›Paper›PMID 32310695›Full record

ReviewCirculation2020

Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management.

Vincent L Aengevaeren, Arend Mosterd, Sanjay Sharma, Niek H J Prakken, Stefan Möhlenkamp, Paul D Thompson, Birgitta K Velthuis, Thijs M H Eijsvogels

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 6 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 6 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021
    Pooled it
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Review
  19. Article
  20. Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Vincent L AengevaerenDepartment of Physiology (V.L.A., T.M.H.E.), Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Arend MosterdDepartment of Cardiology, Meander Medical Center, Amersfoort, The Netherlands (A.M.).
Sanjay SharmaCardiology Clinical and Academic Group, St George's University of London, United Kingdom (S.S.).
Niek H J PrakkenDepartment of Radiology, University Medical Center Groningen, The Netherlands (N.H.J.P.).
Stefan MöhlenkampClinic of Cardiology and Intensive Care Medicine, Bethanien Hospital Moers, Germany (S.M.).
Paul D ThompsonDivision of Cardiology, Hartford Hospital, CT (P.D.T.).
Birgitta K VelthuisDepartment of Radiology, University Medical Center Utrecht, The Netherlands (B.K.V.).
Thijs M H EijsvogelsDepartment of Physiology (V.L.A., T.M.H.E.), Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Hartford Hospital · USUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity and exercise training are effective strategies for reducing the risk of cardiovascular events, but multiple studies have reported an increased prevalence of coronary atherosclerosis, usually measured as coronary artery calcification, among athletes who are middle-aged and older. Our review of the medical literature demonstrates that the prevalence of coronary artery calcification and atherosclerotic plaques, which are strong predictors for future cardiovascular morbidity and mortality, was higher in athletes compared with controls, and was higher in the most active athletes compared with less active athletes. However, analysis of plaque morphology revealed fewer mixed plaques and more often only calcified plaques among athletes, suggesting a more benign composition of atherosclerotic plaques. This review describes the effects of physical activity and exercise training on coronary atherosclerosis in athletes who are middle-aged and older and aims to contribute to the understanding of the potential adverse effects of the highest doses of exercise training on the coronary arteries. For this purpose, we will review the association between exercise and coronary atherosclerosis measured using computed tomography, discuss the potential underlying mechanisms for exercise-induced coronary atherosclerosis, determine the clinical relevance of coronary atherosclerosis in middle-aged athletes and describe strategies for the clinical management of athletes with coronary atherosclerosis to guide physicians in clinical decision making and treatment of athletes with elevated coronary artery calcification scores.

Indexed as

AthletesComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseExercisePlaque, AtheroscleroticFemaleHumansMalePrevalenceRisk FactorsVascular Calcificationathletescomputed tomography angiographycoronary atherosclerosisexercise

Identifiers

PMID32310695
PMCPMC7176353
OpenAlexW3016476762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.