Evidence map›Paper›PMID 32310683›Full record

ReviewExpert review of clinical pharmacology2020

Pharmacologic management of

Tjip S Van Der Werf, Yves T Barogui, Paul J Converse, Richard O Phillips, Ymkje Stienstra

Open access · hybridAbstract readReview
In one paragraph

Review in Expert review of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Life (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Article
  4. Bacterial diversity in Buruli ulcer lesions in Ghana.Journal of clinical tuberculosis and other mycobacterial diseases · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Tjip S Van Der WerfDepartments of Internal Medicine/Infectious Diseases, University Medical Centre Groningen, University of Groningen , Groningen, Netherlands.ORCID https://orcid.org/0000-0002-4824-1642
Yves T BaroguiMinistère De La Sante ́, Programme National Lutte Contre La Lèpre Et l'Ulcère De Buruli , Cotonou, Benin.
Paul J ConverseDepartment of Medicine, Johns Hopkins University Center for Tuberculosis Research , Baltimore, Maryland, USA.
Richard O PhillipsKumasi, Ghana And Kwame Nkrumah University of Science and Technology, Komfo Anokye Teaching Hospital , Kumasi, Ghana.
Ymkje StienstraDepartments of Internal Medicine/Infectious Diseases, University Medical Centre Groningen, University of Groningen , Groningen, Netherlands.
University Medical Center Groningen · NLJohns Hopkins University · USKomfo Anokye Teaching Hospital · GH

Funding

Closing the Gaps on Buruli Ulcer Diagnosis, Treatment, and PreventionR01AI113266 · NIAID · JOHNS HOPKINS UNIVERSITY · PI NUERMBERGER, ERIC L · 2016 to 2020
$4.4M
Medical Research Council MR/J01477X/1NIAID NIH HHS R01 AI113266
6 · The paper itself

Abstract

introductionPharmacological treatment of Buruli ulcer ( AREAS COVERED: We review BU drug treatment - in vitro, in vivo and clinical trials (PubMed: '(Buruli OR (Mycobacterium AND ulcerans)) AND (treatment OR therapy).' We also highlight the pathogenesis of EXPERT OPINION: A combination of rifampicin and clarithromycin is highly effective but lesions still take a long time to heal. Novel drugs like telacebec have the potential to reduce treatment duration but this drug may remain unaffordable in low-resourced settings. Research should address ulcer treatment in general; essays to measure mycolactone over time hold promise to use as a readout for studies to compare drug treatment schedules for larger lesions of Buruli ulcer.

Indexed as

AnimalsAnti-Bacterial AgentsBuruli UlcerDrug RepositioningDrug Therapy, CombinationHumansMacrolidesMycobacterium ulceransRandomized Controlled Trials as TopicWound HealingAnti-Bacterial AgentsMacrolidesmycolactoneBuruli ulcerclinical trialsMycobacterium ulceranspharmacokineticspharmacologytreatment

Identifiers

PMID32310683
PMCPMC9020253
OpenAlexW3016886346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.