ReviewHuman brain mapping2022
The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke.
Abstract readReview
In one paragraph
Review in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis.Journal of the American Heart Association · 2022Pooled it
- Estimating white matter hyperintensities volume in individuals with stroke using T1-weighted images.Neuroimage. Reports · 2026Article
- Optimizing the Approach to Calculating CST Lesion Load in Ischemic Stroke Patients for Understanding Motor Outcomes.Neurorehabilitation and neural repair · 2026Article
- Seric Molecular Markers Correlated with Stroke Rehabilitation Outcomes: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study.The Lancet. Digital health · 2026Observational
- Hippocampal subfield-specific alterations in post-stroke dementia with subcortical lesion.Brain imaging and behavior · 2025Article
- Collaborative AI for precision neurorehabilitation: a roadmap.Journal of neuroengineering and rehabilitation · 2025Review
- Extension of voxel-based lesion mapping to multidimensional neurophysiological data.Scientific reports · 2025Article
- A Personalized Multimodal BCI-Soft Robotics System for Rehabilitating Upper Limb Function in Chronic Stroke Patients.Biomimetics (Basel, Switzerland) · 2025Article
- Sex-specific infarct volume associations and early prediction of language impairment progression following stroke surgery: a network approach.Frontiers in neurology · 2025Article
- Optimizing Automated Hematoma Expansion Classification from Baseline and Follow-Up Head Computed Tomography.Applied sciences (Basel, Switzerland) · 2025Article
- Constructing and exploring neuroimaging projects: a survey from clinical practice to scientific research.Insights into imaging · 2024Review
- Severe motor impairment is associated with lower contralesional brain age in chronic stroke.medRxiv : the preprint server for health sciences · 2024Article
- The Aphasia Recovery Cohort, an open-source chronic stroke repository.Scientific data · 2024Article
- Activity-dependent transcriptional programs in memory regulate motor recovery after stroke.Communications biology · 2024Article
- Modulation of the Association Between Corticospinal Tract Damage and Outcome After Stroke by White Matter Hyperintensities.Neurology · 2024Article
- NSF DARE-Transforming modeling in neurorehabilitation: Four threads for catalyzing progress.Journal of neuroengineering and rehabilitation · 2024Review
- Cortical Sensorimotor Integration as a Neural Origin of Impaired Grip Force Direction Control following Stroke.Brain sciences · 2024Article
- Data-driven biomarkers better associate with stroke motor outcomes than theory-based biomarkers.Brain communications · 2024Article
- Scaling behaviours of deep learning and linear algorithms for the prediction of stroke severity.Brain communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
67 authors.
Sook-Lei LiewChan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-5935-4215
Artemis Zavaliangos-PetropuluDepartment of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Neda JahanshadDepartment of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Catherine E LangProgram in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, USA.
Kathryn S HaywardDepartment of Physiotherapy, and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0001-5240-3264
Keith R LohseDepartment of Health, Kinesiology, and Recreation, University of Utah, Salt Lake City, Utah, USA.
Julia M JulianoNeuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
Francesca AssognaLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Lee A BaughDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, USA.
Anup K BhattacharyaMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Bavrina BigjahanDepartment of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Michael R BorichDepartment of Rehabilitation Medicine, Emory University, Atlanta, Georgia, USA.
Lara A BoydDepartment of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-2828-4549
Amy BrodtmannFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Cathrin M BuetefischDepartment of Rehabilitation Medicine, Emory University, Atlanta, Georgia, USA.
Winston D ByblowDepartment of Exercise Sciences, Centre for Brain Research, University of Auckland, Auckland, New Zealand.
Jessica M CassidyDivision of Physical Therapy, Department Allied Health Sciences, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3469-0399
Adriana B ConfortoNeurology Clinical Division, Hospital das Clínicas/São Paulo University, São Paulo, Brazil.
R Cameron CraddockDepartment of Diagnostic Medicine, The University of Texas at Austin Dell Medical School, Austin, Texas, USA.
Michael A DimyanDepartment of Neurology and Neurorehabilitation, School of Medicine, University of Maryland, Baltimore, Baltimore, Maryland, USA.
Adrienne N DulaDepartment of Diagnostic Medicine, The University of Texas at Austin Dell Medical School, Austin, Texas, USA.
Elsa ErmerDepartment of Neurology and Neurorehabilitation, School of Medicine, University of Maryland, Baltimore, Baltimore, Maryland, USA.
Mark R EthertonDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kelene A FerchoDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, USA.
Chris M GregoryDepartment of Health Sciences and Research, Medical University of South Carolina, Charleston, South Carolina, USA.
Shahram HadidchiDepartment of Radiology, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA.
Jess A HolguinChan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, California, USA.
Darryl H HwangDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Simon JungDepartment of Neurology, University of Bern, Bern, Switzerland.
Steven A KautzDepartment of Health Sciences and Research, Medical University of South Carolina, Charleston, South Carolina, USA.
Mohamed Salah KhlifFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-0096-434X
Nima KhoshabDepartment of Anatomy and Neurobiology, University of California, Irvine, California, USA.
Bokkyu KimDepartment of Physical Therapy Education, State University of New York Upstate Medical University, Syracuse, New York, USA.
Hosung KimDepartment of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Amy KuceyeskiDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-5050-8342
Martin LotzeFunctional Imaging Unit, Center for Diagnostic Radiology, School of Medicine, University of Greifswald, Greifswald, Germany.ORCID 0000-0003-4519-4956
Bradley J MacIntoshDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-7300-2355
John L MargetisChan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, California, USA.
Feroze B MohamedDepartment of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Fabrizio PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Ander Ramos-MurguialdayTECNALIA, Basque Research and Technology Alliance (BRTA), Neurotechnology Laboratory, Derio, Spain.
Geneviève RichardDepartment of Psychology, University of Oslo, Oslo, Norway.ORCID 0000-0001-6475-2576
Pamela RobertsDepartment of Physical Medicine and Rehabilitation, Cedars-Sinai, Los Angeles, California, USA.
Andrew D RobertsonDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
Jane M RondinaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Natalia S RostStroke Division, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nerses SanossianDivision of Neurocritical Care and Stroke, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Nicolas SchweighoferDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA.
Na Jin SeoDepartment of Health Sciences and Research, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0001-6446-5905
Mark S ShiroishiDivision of Neuroradiology, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Surjo R SoekadarDepartment of Psychiatry and Psychotherapy, Clinical Neurotechnology Laboratory, Charité - University Medicine Berlin, Berlin, Germany.
Gianfranco SpallettaLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0002-7432-4249
Cathy M StinearDepartment of Medicine, University of Auckland, Auckland, New Zealand.
Anisha SuriDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Wai Kwong W TangDepartment of Psychiatry, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Gregory T ThielmanPhysical Therapy and Neuroscience, University of the Sciences, Philadelphia, Pennsylvania, USA.
Daniela VecchioLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Nick S WardUCL Queen Square Institute of Neurology, University College London, London, UK.
Emilio WerdenFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.ORCID 0000-0001-8644-956X
Carolee WinsteinDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA.
George F WittenbergDepartment of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kristin A WongDepartment of Physical Medicine and Rehabilitation, Dell Medical School, University of Texas Austin, Austin, Texas, USA.
Chunshui YuDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, China.ORCID 0000-0001-5648-5199
Steven C CramerDepartment of Neurology, UCLA and California Rehabilitation Institute, Los Angeles, California, USA.
Paul M ThompsonDepartment of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Funding
DISCOVERY - Statistics and Analysis CoreU19NS115388 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg, Natalia S Rost · 2019 to 2026
$75.4MTreating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1MTechniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GEORGE, MARK S · 2015 to 2024
$12.7MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MMentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0MRehabilitation Research Resource to Enhance Clinical Trials (ReACT)P2CHD086851 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BAMMAN, MARCAS M · 2015 to 2019
$7.1MMRI-GENetics Interface Exploration_MRI-GENIE_StudyR01NS086905 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROST, NATALIA S · 2015 to 2019
$3.3MSupplement to Effects of global brain health on sensorimotor recovery after strokeR01NS115845 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIEW, SOOK-LEI · 2020 to 2024
$3.2MHigh resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1MCustomized cortical stimulation therapy in the rehabilitation of stroke patientsR01NS090677 · NINDS · EMORY UNIVERSITY · PI BUETEFISCH, CATHRIN M · 2015 to 2018
$3.0MStatins augment small vessel function and improve stroke outcomesR01NS082285 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROST, NATALIA S · 2013 to 2017
$2.6MAmerican Heart Association-American Stroke AssociationCIHR PJT-153330European Research Council ERC-2017-STG-759370European Research Council ERC-STG-802998NCATS NIH HHS KL2 TR001854NIA NIH HHS R01 AG059874NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS K01 HD091283NICHD NIH HHS P2C HD086844NICHD NIH HHS P2C HD086851NICHD NIH HHS R00 HD091375NICHD NIH HHS R01 HD065438NICHD NIH HHS R01 HD095137NICHD NIH HHS R21 HD067906NIGMS NIH HHS P20 GM109040NIH HHS 5P2CHD086851NIH HHS HD065438NIH HHS HD086844NIH HHS K01HD091283NIH HHS K23NS088107NIH HHS P20 GM109040NIH HHS P2CHD06570NIH HHS R00HD091375NIH HHS R01AG059874NIH HHS R01HD065438NIH HHS R01HD095137NIH HHS R01MH117601NIH HHS R01NR015591NIH HHS R01NS076348NIH HHS R01NS082285NIH HHS R01NS086905NIH HHS R01NS090677NIH HHS R01NS115845NIH HHS R21HD067906NIH HHS R56-NS100528NIH HHS U19NS115388NIH HHS U54EB020403NIMH NIH HHS R01 MH117601NINDS NIH HHS K23 NS088107NINDS NIH HHS R01 NS076348NINDS NIH HHS R01 NS082285NINDS NIH HHS R01 NS086905NINDS NIH HHS R01 NS090677NINDS NIH HHS R01 NS115845NINDS NIH HHS R56 NS100528NINDS NIH HHS U19 NS115388NINR NIH HHS R01 NR015591RRD VA I01 RX001667RRD VA IK6 RX003075VA IO1RX001667VA N-1667
Abstract
The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large-scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided.
Indexed as
Magnetic Resonance ImagingNeuroimagingStrokeHumansMulticenter Studies as TopicStroke Rehabilitationbig datalesionsMRIneuroinformaticsstroke
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