ArticleJournal of visualized experiments : JoVE2020
Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors.
Article in Journal of visualized experiments : JoVE, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Terahertz Imaging for Breast Cancer Detection in Animal Models: A Literature Review with Narrative Synthesis.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Synergistic terahertz platforms for precision oncology.Theranostics · 2026Review
- Review
- Polarimetry terahertz imaging of human breast cancer surgical specimens.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Article
- Experimental characterization of a fully polarimetric pulsed terahertz spectroscopy system.Frontiers in physics · 2024Article
- Biomedical application of terahertz imaging technology: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Clinical and experimental study of a terahertz time-domain system for the determination of the pathological margins of laryngeal carcinoma.World journal of surgical oncology · 2022Article
- Hyperspectral terahertz imaging and optical clearance for cancer classification in breast tumor surgical specimen.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Deep Learning Classification of Breast Cancer Tissue from Terahertz Imaging Through Wavelet Synchro-Squeezed Transformation and Transfer Learning.Journal of infrared, millimeter and terahertz waves · 2022Article
- Early detection of gastric cancerFrontiers in bioengineering and biotechnology · 2022Article
- Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This manuscript presents a protocol to handle, characterize, and image freshly excised human breast tumors using pulsed terahertz imaging and spectroscopy techniques. The protocol involves terahertz transmission mode at normal incidence and terahertz reflection mode at an oblique angle of 30°. The collected experimental data represent time domain pulses of the electric field. The terahertz electric field signal transmitted through a fixed point on the excised tissue is processed, through an analytical model, to extract the refractive index and absorption coefficient of the tissue. Utilizing a stepper motor scanner, the terahertz emitted pulse is reflected from each pixel on the tumor providing a planar image of different tissue regions. The image can be presented in time or frequency domain. Furthermore, the extracted data of the refractive index and absorption coefficient at each pixel are utilized to provide a tomographic terahertz image of the tumor. The protocol demonstrates clear differentiation between cancerous and healthy tissues. On the other hand, not adhering to the protocol can result in noisy or inaccurate images due to the presence of air bubbles and fluid remains on the tumor surface. The protocol provides a method for surgical margins assessment of breast tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.