Evidence map›Paper›PMID 32310162›Full record

Trial reportJournal of Alzheimer's disease : JAD2020

Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.

Binu P Thomas, Takashi Tarumi, Min Sheng, Benjamin Tseng, Kyle B Womack, C Munro Cullum, Bart Rypma, Rong Zhang, Hanzhang Lu

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 8 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 8 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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  10. One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Binu P ThomasAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Takashi TarumiInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA.
Min ShengAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Benjamin TsengInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA.
Kyle B WomackDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
C Munro CullumDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bart RypmaDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rong ZhangInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA.
Hanzhang LuAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The University of Texas Southwestern Medical Center · USInstitute for Exercise and Environmental Medicine · USJohns Hopkins Medicine · USPresbyterian Hospital · USThe University of Texas at Arlington · USThe University of Texas at Dallas · US

Funding

Normalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6M
Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise TrainingR01AG033106 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, ZHANG, RONG · 2009 to 2012
$3.1M
An integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7M
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseR01AG064792 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2020 to 2023
$2.6M
MR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2M
BOLD and its discontents: age-differences in the neurophysiology of fMRI signalR01AG047972 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, RYPMA, BART · 2015 to 2019
$1.7M
Brain oxygen consumption as an MRI biomarker of neurodegeneration in a model of Alzheimer?s diseaseR21AG058413 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2019
$465k
NIA NIH HHS R01 AG033106NIA NIH HHS R01 AG047972NIA NIH HHS R01 AG064792NIA NIH HHS R21 AG058413NIMH NIH HHS R01 MH084021NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711
6 · The paper itself

Abstract

Aerobic exercise (AE) has recently received increasing attention in the prevention of Alzheimer's disease (AD). There is some evidence that it can improve neurocognitive function in elderly individuals. However, the mechanism of these improvements is not completely understood. In this prospective clinical trial, thirty amnestic mild cognitive impairment participants were enrolled into two groups and underwent 12 months of intervention. One group (n = 15) performed AE training (8M/7F, age = 66.4 years), whereas the other (n = 15) performed stretch training (8M/7F, age = 66.1 years) as a control intervention. Both groups performed 25-30 minutes training, 3 times per week. Frequency and duration were gradually increased over time. Twelve-month AE training improved cardiorespiratory fitness (p = 0.04) and memory function (p = 0.004). Cerebral blood flow (CBF) was measured at pre- and post-training using pseudo-continuous-arterial-spin-labeling MRI. Relative to the stretch group, the AE group displayed a training-related increase in CBF in the anterior cingulate cortex (p = 0.016). Furthermore, across individuals, the extent of memory improvement was associated with CBF increases in anterior cingulate cortex and adjacent prefrontal cortex (voxel-wise p < 0.05). In contrast, AE resulted in a decrease in CBF of the posterior cingulate cortex, when compared to the stretch group (p = 0.01). These results suggest that salutary effects of AE in AD may be mediated by redistribution of blood flow and neural activity in AD-sensitive regions of brain.

Indexed as

AgedAged, 80 and overBrainCardiorespiratory FitnessCerebrovascular CirculationCognitive DysfunctionExerciseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsProspective StudiesSingle-Blind MethodSpin LabelsSpin LabelsAerobic exercise trainingAlzheimer’s diseaseamnestic mild cognitive impairmentanterior cingulate cortexcerebral blood flowposterior cingulate cortexstretch training

Identifiers

PMID32310162
PMCPMC8062932
OpenAlexW3017217475

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.