Evidence map›Paper›PMID 32309888›Full record

SynthesisJournal of clinical laboratory analysis2020

Diagnostic performance of circulating exosomes in human cancer: A meta-analysis.

Dongming Guo, Jinpeng Yuan, Aosi Xie, Zeyin Lin, Xinxin Li, Juntian Chen

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Diagnostic value of exosomes in patients with liver cancer: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dongming GuoDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Jinpeng YuanDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Aosi XieDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Zeyin LinDepartment of Ultrasound, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Xinxin LiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Juntian ChenDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.ORCID https://orcid.org/0000-0002-3197-9421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer has become a public health problem with high morbidity and mortality. Recent publications have shown that exosomes can be used as potential diagnostic biomarkers of cancer. However, the diagnostic accuracy and reliability of circulating exosomes remain unclear. The present meta-analysis was conducted to comprehensively summarize the overall diagnostic performance of circulating exosomes for cancer.

methodsEligible studies published up to June 27, 2019, on PubMed, Embase, and Cochrane Library were selected for the meta-analysis. All statistical analyses were performed by STATA 15.1 statistical software and Meta-DiSc 1.4. Quality Assessment for Studies of Diagnostic Accuracy 2 tool was used to access the quality of included studies. A bivariate mixed-effects model was applied to calculate the diagnostic indexes from included studies.

resultsA total of 5924 participants comprising 3161 cases and 2763 controls from 42 eligible studies were analyzed. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the area under the curve with 95% confidence intervals (95% CI) were as follows: 0.79 (0.75-0.82), 0.81 (0.78-0.84), 4.1 (3.5-4.8), 0.26 (0.22-0.31), 16 (12-21), and 0.87 (0.84-0.89), respectively. Sensitivity analysis suggested no study exclusively contributed to the heterogeneity, and Deeks' funnel plot asymmetry test indicated no potential publication bias (P = .09).

conclusionsThe meta-analysis indicated that circulating exosomes could serve as effective and minimally invasive biomarkers for diagnosis of cancer, especially in patients with hepatocellular carcinoma or ovarian cancer, serum-based samples and exosomal proteins.

Indexed as

ExosomesNeoplasmsBiomarkers, TumorHumansBiomarkers, Tumorcancercarcinomacirculatingdiagnosisexosomemeta-analysis

Identifiers

PMID32309888
PMCPMC7439344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.