ArticleJournal of experimental botany2020
The CLE53-SUNN genetic pathway negatively regulates arbuscular mycorrhiza root colonization in Medicago truncatula.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- From invitation to eviction: How plants control arbuscular mycorrhizal symbiosis.Plant signaling & behavior · 2026Review
- Peptide hormones in shaping root system architecture and environmental adaptation: Current advances and translational perspectives.Plant communications · 2026Review
- Elevated COProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Article
- Molecular mechanisms modulating beneficial plant root-microbe interactions: What's common?Plant communications · 2026Review
- Upstairs, downstairs: conserved and divergent CLAVATA signalling in shoot meristem development and root symbioses.Annals of botany · 2025Review
- Pan-Angiosperm Analysis of the CLE Signaling Peptide Gene Family Unveils Paths, Patterns, and Predictions of Paralog Diversification.Molecular biology and evolution · 2025Article
- Non-rhizobial endophyte recruitment and diversity in Pisum sativum are strongly shaped by phosphorus fertilizer form.Environmental microbiome · 2025Article
- Peptides in plant-microbe interactions: Functional diversity and pharmacological applications.Cell surface (Amsterdam, Netherlands) · 2025Review
- The white lupin CCR1 receptor-like kinase controls systemic Autoregulation of Cluster Root and Nodule Development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN-mediated ROS suppression.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Decoding small peptides: Regulators of plant growth and stress resilience.Journal of integrative plant biology · 2025Review
- The Small Key to the Treasure Chest: Endogenous Plant Peptides Involved in Symbiotic Interactions.Plants (Basel, Switzerland) · 2025Review
- The Defective in Autoregulation (DAR) gene of Medicago truncatula encodes a protein involved in regulating nodulation and arbuscular mycorrhiza.BMC plant biology · 2024Article
- Spatial co-transcriptomics reveals discrete stages of the arbuscular mycorrhizal symbiosis.Nature plants · 2024Article
- CLAVATA signaling in plant-environment interactions.Plant physiology · 2024Review
- The Role of CLE Peptides in the Suppression of Mycorrhizal Colonization of Tomato.Plant & cell physiology · 2024Article
- Article
- CLE peptide signaling in plant-microbe interactions.Frontiers in plant science · 2024Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants and arbuscular mycorrhizal fungi (AMF) engage in mutually beneficial symbioses based on a reciprocal exchange of nutrients. The beneficial character of the symbiosis is maintained through a mechanism called autoregulation of mycorrhization (AOM). AOM includes root-to-shoot-to-root signaling; however, the molecular details of AOM are poorly understood. AOM shares many features of autoregulation of nodulation (AON) where several genes are known, including the receptor-like kinase SUPER NUMERIC NODULES (SUNN), root-to-shoot mobile CLAVATA3/ENDOSPERM SURROUNDING REGION (ESR)-RELATED (CLE) peptides, and the hydroxyproline O-arabinosyltransferase ROOT DETERMINED NODULATION1 (RDN1) required for post-translational peptide modification. In this work, CLE53 was identified to negatively regulate AMF symbiosis in a SUNN- and RDN1-dependent manner. CLE53 expression was repressed at low phosphorus, while it was induced by AMF colonization and high phosphorus. CLE53 overexpression reduced AMF colonization in a SUNN- and RDN1 dependent manner, while cle53, rdn1, and sunn mutants were more colonized than the wild type. RNA-sequencing identified 700 genes with SUNN-dependent regulation in AMF-colonized plants, providing a resource for future identification of additional AOM genes. Disruption of AOM genes in crops potentially constitutes a novel route for improving AMF-derived phosphorus uptake in agricultural systems with high phosphorus levels.
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Registered trials
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