Evidence map›Paper›PMID 32309852›Full record

Observational studyBioscience reports2020

Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets.

Yawei Wang, Haiyan Zhang, Jian Wang, Bei Li, Xiuwen Wang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Review
  17. Emerging Roles of Exosomal Circular RNAs in Cancer.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yawei WangDepartment of Medical Oncology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
Haiyan ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong 250021, China.
Jian WangDepartment of Medical Oncology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
Bei LiDepartment of Medical Oncology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.
Xiuwen WangDepartment of Medical Oncology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidences indicated that exosomal circular RNAs (circRNAs) could serve as diagnostic biomarkers for cancers. However, the expression profiles and clinical significance of circRNAs in lung squamous cell carcinoma (LUSC) remain largely unknown. Herein, we analyzed circRNAs expression profile in six pairs of plasma exosome samples of LUSC patients using high-throughput sequencing. A total of 252 differentially expressed exosomal circRNAs were identified, including 133 up-regulated circRNAs and 119 down-regulated circRNAs. Subsequently, the circRNAs-miRNAs-mRNAs interaction network was built to investigate potential function of circRNAs. Three up-regulated circRNAs (hsa_circ_0014235, hsa_circ_0025580 and hsa_circ_0026403) were implied to participate in cancer-related pathways. QRT-PCR experiment confirmed the up-regulation of hsa_circ_0014235 and hsa_circ_0025580. Finally, clinical studies indicated that hsa_circ_0014235 and hsa_circ_0025580 could serve as novel diagnostic biomarkers for LUSC. Taken together, our study revealed exosomal circRNAs expression profile in LUSC for the first time and showed the important diagnostic potential for circRNAs in LUSC.

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesCell-Free Nucleic AcidsDown-RegulationExosomesFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansLung NeoplasmsMaleMicroRNAsMiddle AgedRNA, CircularRNA, MessengerBiomarkers, TumorCell-Free Nucleic AcidsMicroRNAsRNA, CircularRNA, MessengerbiomarkerscircRNAs profilehsa_circ_0014235hsa_circ_0025580LUSC

Identifiers

PMID32309852
PMCPMC7189478

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.