ArticleACS omega2020
In Vitro Investigation of Hemocompatibility of Hydrothermally Treated Titanium and Titanium Alloy Surfaces.
Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Nano-engineering the titanium-tissue interface: a 15 year perspective on bio-functionalization and surface innovation.Nanoscale advances · 2026Review
- The dental implant surface: a review of the past, present and future.Journal of materials science. Materials in medicine · 2026Review
- Advances in Dealloying of Ti and Ti-Based Alloys for Biomedical Applications.Materials (Basel, Switzerland) · 2025Review
- Multifunctional micro/nano-textured titanium with bactericidal, osteogenic, angiogenic and anti-inflammatory properties: Insights fromMaterials today. Bio · 2025Article
- Anti-Bacterial Properties and Hemocompatibility of Alkali Treated Nano-Structured Micro-Porous Titanium Surfaces.Biomimetics (Basel, Switzerland) · 2025Article
- Endothelial and smooth muscle cell interaction with hydrothermally treated titanium surfaces.In vitro models · 2024Article
- Unravelling Surface Modification Strategies for Preventing Medical Device-Induced Thrombosis.Advanced healthcare materials · 2024Review
- Stainless steel and titanium alloys coated with sulfated chitosan to improve hemocompatibility properties.In vitro models · 2023Article
- Zinc (Zn) Doping by Hydrothermal and Alkaline Heat-Treatment Methods on Titania Nanotube Arrays for Enhanced Antibacterial Activity.Nanomaterials (Basel, Switzerland) · 2023Article
- Improved Hemocompatibility on Superhemophobic Micro-Nano-Structured Titanium Surfaces.Bioengineering (Basel, Switzerland) · 2022Article
- Erythrocyte interaction with titanium nanostructured surfaces.In vitro models · 2022Article
- Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces.Cells · 2022Article
- Synthesis and Properties of Hydrogels on Medical Titanium Alloy Surface by Modified Dopamine Adhesion.Gels (Basel, Switzerland) · 2022Article
- Surface-modified WE43 magnesium alloys for reduced degradation and superior biocompatibility.In vitro models · 2022Article
- Manganese-containing Bioactive Glass Enhances Osteogenic Activity of TiOApplied surface science · 2021Article
- Surface modification strategies to improve titanium hemocompatibility: a comprehensive review.Materials advances · 2021Review
- Hydrothermally treated titanium surfaces for enhanced osteogenic differentiation of adipose derived stem cells.Materials science & engineering. C, Materials for biological applications · 2021Article
- Titanium and Protein Adsorption: An Overview of Mechanisms and Effects of Surface Features.Materials (Basel, Switzerland) · 2021Review
- Improved hemocompatibility and reduced bacterial adhesion on superhydrophobic titania nanoflower surfaces.Materials science & engineering. C, Materials for biological applications · 2021Article
- Tanfloc/heparin polyelectrolyte multilayers improve osteogenic differentiation of adipose-derived stem cells on titania nanotube surfaces.Carbohydrate polymers · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
For decades, titanium and its alloys have been established as a biocompatible material for cardiovascular medical devices such as heart valves, stents, vascular grafts, catheters, etc. However, thrombosis is one of the reasons for implant failure, where blood clot forms on the implant surface, thus obstructing the flow of the blood and that leads to some serious complications. Various surface modification techniques such as heparin modification, albumin coating, surface anodization, plasma etching, and hydrothermal treatments have been explored to improve the hemocompatibility of titanium-based materials. However, there are several limitations related to the robustness of the surfaces and long-term efficacy in vivo. In this study, titanium and its alloy Ti-6Al-4V were hydrothermally treated to form nanostructured surfaces with the aim to enhance their hemocompatibility. These modified surfaces were characterized for their wettability, surface morphology, surface chemistry, and crystallinity. The hemocompatibility of these surfaces was characterized by evaluating blood plasma protein adsorption, platelet adhesion and activation, platelet-leukocyte complex formation, and whole blood clotting. The results indicate lower fibrinogen adsorption, cell adhesion, platelet activation, and whole blood clotting on hydrothermally treated surfaces. Thus, these surfaces may be a promising approach to prevent thrombosis for several titanium blood-contacting medical devices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.