ArticlePeerJ2020
Validation of a handheld β-hydroxybutyrate acid meter to identify hyperketonaemia in ewes.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Comparative Evaluation of Different Blood Collection Sites for the Assessment of Beta-Hydroxybutyric Acid Concentrations Using a Handheld Meter in Sheep.Veterinary medicine and science · 2025Article
- Quantitative differences in rumen epithelium proteins and detection of lysine acetylation in lambs fed a low or high metabolizable energy diet.Journal of animal science · 2025Article
- Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies.Metabolites · 2023Review
- Use of AgomiR and AntagomiR technologies to alter satellite cell proliferationFrontiers in molecular biosciences · 2023Article
- Extensive Sheep and Goat Production: The Role of Novel Technologies towards Sustainability and Animal Welfare.Animals : an open access journal from MDPI · 2022Review
- Maternal Supplementation with Dietary Betaine during Gestation to Improve Twin Lamb Survival.Animals : an open access journal from MDPI · 2020Article
- Metabolic Profile of Steers Subjected to Normal Feeding, Fasting, and Re-Feeding Conditions.Veterinary sciences · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe end of pregnancy is the period with the highest risk of occurrences of ketosis and pregnancy toxemia due to fat mobilization and increasing non-esterified fatty acids in the liver which are converted in ketone bodies, mainly β-hydroxybutyrate acid (BHB). This ketone body may also become elevated in the bloodstream. The present study validates the use of a handheld meter for determining the blood concentration of BHB and ascertaining the predictive value and accuracy of BHB measurements in diagnosing hyperketonaemia in ewes.
methodsA total of 19, non-pregnant, crossbred ewes were subjected to 2 h of intravenous infusion of a saturated BHB solution. Over 6 h of evaluation, 247 blood samples were obtained in 13 sampling moments. The BHB concentration was measured by an enzymatic colorimetric method in an automated biochemical analyzer (gold-standard) and by a handheld meter using an electrochemical enzyme technique.
resultsThere was a high correlation between both methods (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.