ArticleComputational and structural biotechnology journal2020
CirRNAPL: A web server for the identification of circRNA based on extreme learning machine.
Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- EIciRNAs in focus: current understanding and future perspectives.RNA biology · 2025Review
- Interpretation of RNA Universe and Coding Potential Using IntRNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Definer: A computational method for accurate identification of RNA pseudouridine sites based on deep learning.PloS one · 2025Article
- Circular RNAs: Biogenesis and Functions : Circular RNA detection and bioinformatic analysis.Advances in experimental medicine and biology · 2025Review
- AlzGenPred - CatBoost-based gene classifier for predicting Alzheimer's disease using high-throughput sequencing data.Scientific reports · 2024Article
- Computational approaches and challenges in the analysis of circRNA data.BMC genomics · 2024Review
- CircRNA identification and feature interpretability analysis.BMC biology · 2024Article
- Identification, characterization and expression analysis of circRNA encoded by SARS-CoV-1 and SARS-CoV-2.Briefings in bioinformatics · 2024Article
- New insight into circRNAs: characterization, strategies, and biomedical applications.Experimental hematology & oncology · 2023Review
- iCircDA-NEAE: Accelerated attribute network embedding and dynamic convolutional autoencoder for circRNA-disease associations prediction.PLoS computational biology · 2023Article
- Computational approaches for circRNAs prediction and in silico characterization.Briefings in bioinformatics · 2023Review
- CircPCBL: Identification of Plant CircRNAs with a CNN-BiGRU-GLT Model.Plants (Basel, Switzerland) · 2023Article
- Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy.RNA biology · 2023Review
- StackCirRNAPred: computational classification of long circRNA from other lncRNA based on stacking strategy.BMC bioinformatics · 2022Article
- Circ-LocNet: A Computational Framework for Circular RNA Sub-Cellular Localization Prediction.International journal of molecular sciences · 2022Article
- Biological Sequence Classification: A Review on Data and General Methods.Research (Washington, D.C.) · 2022Article
- CRBPDL: Identification of circRNA-RBP interaction sites using an ensemble neural network approach.PLoS computational biology · 2022Article
- A Brief Review of circRNA Biogenesis, Detection, and Function.Current genomics · 2021Review
- Attention-Based Deep Multiple-Instance Learning for Classifying Circular RNA and Other Long Non-Coding RNA.Genes · 2021Article
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8 authors.
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Abstract
Circular RNA (circRNA) plays an important role in the development of diseases, and it provides a novel idea for drug development. Accurate identification of circRNAs is important for a deeper understanding of their functions. In this study, we developed a new classifier, CirRNAPL, which extracts the features of nucleic acid composition and structure of the circRNA sequence and optimizes the extreme learning machine based on the particle swarm optimization algorithm. We compared CirRNAPL with existing methods, including blast, on three datasets and found CirRNAPL significantly improved the identification accuracy for the three datasets, with accuracies of 0.815, 0.802, and 0.782, respectively. Additionally, we performed sequence alignment on 564 sequences of the independent detection set of the third data set and analyzed the expression level of circRNAs. Results showed the expression level of the sequence is positively correlated with the abundance. A user-friendly CirRNAPL web server is freely available at http://server.malab.cn/CirRNAPL/.
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