Evidence map›Paper›PMID 32308880›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2019

Integrating Clinical Knowledge and Real-World Evidence for Type 2 Diabetes Treatment.

Xingzhi Sun, Wei Zhao, Lei Zuo, Alexandra Dumitriu, Chuang-Chung Lee, Nan Cui, Xiyang Liao, Tingting Zhao, Xuehan Jiang, Zhuoyang Xu and 4 more

Open access · greenAbstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. A Guideline-Based Decision Tree Achieves Better Glucose Control with Less Hypoglycemia at 3 Months in Chinese Diabetic Patients.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Xingzhi SunPing An Health Technology, Beijing, China.
Wei ZhaoPing An Health Technology, Beijing, China.
Lei ZuoPing An Health Technology, Beijing, China.
Alexandra DumitriuSanofi, Cambridge, Massachusetts, U.S.A.
Chuang-Chung LeeSanofi, Cambridge, Massachusetts, U.S.A.
Nan CuiSanofi (China) Investment, Shanghai, China.
Xiyang LiaoPing An Health Technology, Beijing, China.
Tingting ZhaoPing An Health Technology, Beijing, China.
Xuehan JiangPing An Health Technology, Beijing, China.
Zhuoyang XuPing An Health Technology, Beijing, China.
Gang HuPing An Health Technology, Beijing, China.
Guotong XiePing An Health Technology, Beijing, China.
Hong WuSanofi (China) Investment, Shanghai, China.
Yahua HuangSanofi (China) Investment, Shanghai, China.
Ping An (China)Sanofi (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical decision support system (CDSS) plays a significant role nowadays and it assists physicians in making decisions for treatment. Generally based on clinical guideline, the principles of the recommendation are provided and may suggest several candidate medications for similar patient group with certain clinical conditions. However, it is challenging to prioritize these candidates and even refine the guideline to a finer level for patient-specific recommendation. Here we propose a method and system to integrate the clinical knowledge and real-world evidence (RWE) for type 2 diabetes treatment, to enable both standardized and personalized medication recommendation. The RWE is generated by medication effectiveness analysis and subgroup analysis. The knowledge model has been verified by clinical experts from the advanced hospitals. The data verification results show that the medications that are consistent with the method recommendation can lead to better clinical outcome in terms of glycemic control, compared to those inconsistent.

Indexed as

Decision Support Systems, ClinicalDrug Therapy, Computer-AssistedEvidence-Based MedicinePrecision MedicineBlood GlucoseClinical Decision-MakingDiabetes Mellitus, Type 2Glycated HemoglobinHumansHypoglycemic AgentsBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic Agents

Identifiers

PMID32308880
PMCPMC7153065
OpenAlexW3027933591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.