Evidence map›Paper›PMID 32308799›Full record

ArticleOxidative medicine and cellular longevity2020

4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.

Ilona Domracheva, Iveta Kanepe-Lapsa, Reinis Vilskersts, Imanta Bruvere, Egils Bisenieks, Astrida Velena, Baiba Turovska, Gunars Duburs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ilona DomrachevaLatvian Institute of Organic Synthesis, Group of Experimental Chemotherapy, Aizkraukles Iela 21, Riga, Latvia LV-1006.ORCID https://orcid.org/0000-0001-5022-5206
Iveta Kanepe-LapsaLatvian Institute of Organic Synthesis, Group of Experimental Chemotherapy, Aizkraukles Iela 21, Riga, Latvia LV-1006.ORCID https://orcid.org/0000-0002-0022-2813
Reinis VilskerstsLatvian Institute of Organic Synthesis, Laboratory of Pharmaceutical Pharmacology, Aizkraukles Iela 21, Riga, Latvia LV-1006.ORCID https://orcid.org/0000-0001-9174-4985
Imanta BruvereLatvian Institute of Organic Synthesis, Laboratory of Membrane Active Compounds and β-Diketones, Aizkraukles Iela 21, Riga, Latvia LV-1006.
Egils BisenieksLatvian Institute of Organic Synthesis, Laboratory of Membrane Active Compounds and β-Diketones, Aizkraukles Iela 21, Riga, Latvia LV-1006.
Astrida VelenaLatvian Institute of Organic Synthesis, Laboratory of Membrane Active Compounds and β-Diketones, Aizkraukles Iela 21, Riga, Latvia LV-1006.ORCID https://orcid.org/0000-0003-1392-1936
Baiba TurovskaLatvian Institute of Organic Synthesis, Laboratory of Physical-Organic Chemistry, Aizkraukles Iela 21, Riga, Latvia LV-1006.
Gunars DubursLatvian Institute of Organic Synthesis, Laboratory of Membrane Active Compounds and β-Diketones, Aizkraukles Iela 21, Riga, Latvia LV-1006.ORCID https://orcid.org/0000-0002-3071-6056
Latvijas Organiskās Sintēzes Institūts · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A set of six new 4-pyridinio-1,4-dihydropyridine (1,4-DHP) compounds has been synthesized. The calcium channel modulating activity of these compounds was evaluated in an aorta vascular smooth muscle cell line (A7R5), in an isolated rat aortic ring model, and in human neuroblastoma cell lines (SH-SY5Y). The antagonistic effect of these 1,4-DHP was tested by modulating the impact of carbachol-dependent mobilization of intracellular Ca

Indexed as

AnimalsCalciumDihydropyridinesHumansIon TransportRatsTumor Cells, Cultured1,4-dihydropyridineCalciumDihydropyridines

Identifiers

PMID32308799
PMCPMC7139875
OpenAlexW3014014448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.