ReviewThe Journal of clinical and aesthetic dermatology2020
Keloids: A Review of Etiology, Prevention, and Treatment.
Review in The Journal of clinical and aesthetic dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06230146 (Efficacy and Safety of Fractional CO2 Laser Combined With Intralesional Insulin, Botulinum Toxin or Triamcinolone Acetonide in the Treatment of Keloid), which is not on this map. Cited by 74 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Fractional CO2 Laser Combined With Intralesional Insulin, Botulinum Toxin or Triamcinolone Acetonide in the Treatment of Keloid: A Clinical, Dermoscopic and Immunohistochemical Study.
Who cites it
74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Therapeutic methods and effect on keloid and hypertrophic scars: a systematic review.Frontiers in medicine · 2026Pooled it
- The role of IL-17 and Th17 cells in keloid pathogenesis.Archives of dermatological research · 2024Pooled it
- Keloid treatments: an evidence-based systematic review of recent advances.Systematic reviews · 2023Pooled it
- Silicone gel sheeting for treating keloid scars.The Cochrane database of systematic reviews · 2023Pooled it
- A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars.Lasers in medical science · 2022Pooled it
- Intralesional 5-Fluorouracil for Keloids: A Systematic Review.Journal of cutaneous medicine and surgeryPooled it
- Combination of fractional carbon dioxide laser and topical triamcinolone vs intralesional triamcinolone for keloid treatment: A randomised clinical trial.International wound journal · 2022Trial
- Trial
- Efficacy of peri-operative high-dose-rate interstitial brachytherapy in keloids: Can we scare the bad scar?Journal of contemporary brachytherapy · 2026Article
- Review
- Polarimetric imaging of collagen in histopathology specimens: an investigation of congo red and picrosirius red-stained placenta and skin.Scientific reports · 2026Article
- Punch Excision Combined With Radiotherapy for Keloid Treatment.Journal of cosmetic dermatology · 2026Article
- Special Issue: The Role of Cytokines in Disease.International journal of molecular sciences · 2026Article
- Analysis of the factors influencing reoperation for severe finger scar contracture in children-clinical data analysis of 61 children.Frontiers in pediatrics · 2026Article
- Assessing Mitochondrial Function, Oxidative Stress and Vitamin D Status in Dark-Skinned Patients With Keloid Disease.Dermatology research and practice · 2026Article
- A Simple and Feasible Earlobe Keloid Pressure Splint.Plastic surgery (Oakville, Ont.) · 2025Article
- Therapeutic effect of hydroxyurea in treating refractory keloids.JAAD case reports · 2025Article
- Complications of auricular cartilage harvest in rhinoplasty: Keloid and epidermal cyst formation.World journal of clinical cases · 2025Article
- Ear Keloids Treated with Postoperative Electrons: A Case Series.South Asian journal of cancer · 2025Article
- Long-Term Outcome of Anterior Chest Keloid Excision Using Intercostal Artery Perforator Propeller Flaps.Aesthetic plastic surgery · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keloids are abnormal scars that cause significant emotional and physical distress in patients when inadequately treated. Keloid formation is theorized to occur as a result of an imbalance between an increased synthesis of collagen and extracellular matrix and decreased degradation of these products. Inflammatory mediators- namely, transforming growth factor beta-have been proposed to influence the dysregulation of collagen remodeling in the scar healing process. Though limited, current knowledge of keloid pathophysiology has guided clinicians to explore novel therapies for keloid prevention and treatment. In addition to conducting research refining the use of common therapies, such as steroids and radiation, clinicians have evaluated the potential of anti-inflammatory and chemotherapeutic molecules to suppress keloid recurrence. Procedural focused therapies, such as cryotherapy and lasers, have also found a role in reducing keloid symptomatology. The purpose of this report is to examine the current literature and review the mechanisms of action, efficacy, and side effects of different keloid therapies. Despite the growing literature investigating reliable methods for keloid management, there are no standardized guidelines or treatment protocols supported by academic governing bodies. Stronger evidence with high-fidelity randomized clinical trials will be needed to determine the optimal therapy regimens for keloids.
Indexed as
Identifiers
32308783PMC7158916W3026660455What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.