Evidence map›Paper›PMID 32308665›Full record

ArticleDementia and geriatric cognitive disorders extra

Age-Related Changes in Instrumental and Basic Activities of Daily Living Impairment in Older Adults with Very Mild Alzheimer's Disease.

Takayuki Tabira, Maki Hotta, Miki Murata, Kazuhiro Yoshiura, Gwanghee Han, Tomohisa Ishikawa, Asuka Koyama, Noriyuki Ogawa, Michio Maruta, Yuriko Ikeda and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Health Promotion and Diagnosis of Oral Diseases in Institutionalized Elderly People: An Experience Report.International journal of environmental research and public health · 2025
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  8. Interventions to Improve Physical Capability of Older Adults with Mild Disabilities: A Case Study.International journal of environmental research and public health · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Diagnosis of Early Alzheimer's Disease: Clinical Practice in 2021.The journal of prevention of Alzheimer's disease
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Takayuki TabiraDepartment of Clinical Neuropsychiatry, Graduate School of Health Sciences, Kagoshima University, Kagoshima, Japan.
Maki HottaDepartment of Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan.
Miki MurataDepartment of Occupational Therapy, Kumamoto Seimei Hospital, Kumamoto Seimei, Japan.
Kazuhiro YoshiuraDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Gwanghee HanDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Tomohisa IshikawaDepartment of Neuropsychiatry, Kumamoto University Hospital, Kumamoto, Japan.
Asuka KoyamaDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Noriyuki OgawaDepartment of Occupational Therapy, Faculty of Health Sciences, Kyoto Tachibana University, Kyoto, Japan.
Michio MarutaDepartment of Clinical Neuropsychiatry, Graduate School of Health Sciences, Kagoshima University, Kagoshima, Japan.
Yuriko IkedaDepartment of Clinical Neuropsychiatry, Graduate School of Health Sciences, Kagoshima University, Kagoshima, Japan.
Takaaki MoriDepartment of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Ehime, Japan.
Taku YoshidaDepartment of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Ehime, Japan.
Mamoru HashimotoDepartment of Behavioral Neurology and Neuropsychiatry, Osaka University, Osaka, Japan.
Manabu IkedaDepartment of Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kagoshima University · JPKumamoto University · JPThe University of Osaka · JPEhime University · JPKumamoto University Hospital · JPKyoto Tachibana University · JPSaiseikai Kumamoto Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsAge-related changes in impairments in activities of daily living (ADL) in older adults with very mild Alzheimer's disease (vmAD) have been scarcely explored. We clarified the characteristics of ADL impairment and examined how ADL impairments differed by age in such patients compared with community-dwelling cognitively normal older adults.

methodsThe participants were 107 older adults with vmAD (Mini-Mental State Examination [MMSE] score ≥24), all of whom were first-visit outpatients at the Dementia Clinic of the Department of Neuropsychiatry, Kumamoto University Hospital. The controls were 682 community-dwelling older adults who participated in the 3rd Nakayama Study with MMSE score ≥24. We examined the association of instrumental and basic ADL (IADL and BADL, respectively) independence with the odds of vmAD using multiple logistic regression analysis and determined differences in ADL impairment by age using age- and sex-matched analysis.

resultsImpairments in handling finances (OR 57.08), managing medication (OR 5.13), and dressing (OR 3.35; BADL) were associated with greater odds of vmAD. Among those aged 65 years and above, there were fewer patients with vmAD than healthy controls who could independently handle finances and medication. Among patients with vmAD, the percentages of those who could independently manage shopping, food preparation, and housekeeping only decreased after age 74. Age-related decreases in independence were observed in few BADL items; these, however, were temporary.

conclusionsPatients with vmAD show significantly decreased IADL independence from early old age.

Indexed as

Activities of daily livingAgingVery mild Alzheimer's disease

Identifiers

PMID32308665
PMCPMC7154273
OpenAlexW3013297375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.