Evidence map›Paper›PMID 32308543›Full record

ArticleInternational journal of medical sciences2020

Tranexamic Acid Inhibits Angiogenesis and Melanogenesis

Jian-Wei Zhu, Ya-Jie Ni, Xiao-Yun Tong, Xia Guo, Xiao-Ping Wu, Zhong-Fa Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  16. Oxidative stress in melanogenesis and melanoma development.Contemporary oncology (Poznan, Poland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jian-Wei ZhuDepartment of Dermatology, Zhejiang Hospital, No. 12, Lingyin Rd., Hangzhou, 310013, Zhejiang Province, China.
Ya-Jie NiDepartment of Dermatology, Zhejiang Hospital, No. 12, Lingyin Rd., Hangzhou, 310013, Zhejiang Province, China.
Xiao-Yun TongDepartment of Dermatology, Zhejiang Hospital, No. 12, Lingyin Rd., Hangzhou, 310013, Zhejiang Province, China.
Xia GuoDepartment of Dermatology, Zhejiang Hospital, No. 12, Lingyin Rd., Hangzhou, 310013, Zhejiang Province, China.
Xiao-Ping WuDepartment of Dermatology, Zhejiang Hospital, No. 12, Lingyin Rd., Hangzhou, 310013, Zhejiang Province, China.
Zhong-Fa LuDepartment of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Rd., Hangzhou, 310009, Zhejiang Province, China.
Zhejiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melasma is a common but complex skin condition concerning cosmetic problems. Tranexamic acid (TA) has been proved to be effective in treatment of melasma with still unclear mechanisms. Here, we show that VEGF165 enhanced the expression of VEGF receptors (VEGFRs, including VEGFR-1, VEGFR-2 and NRP-1) in human umbilical vein endothelial cells (HUVECs), which was attenuated by TA. VEGF165 also promoted tyrosine phosphorylation of VEGFR-1 and VEGFR-2 in HUVECs, which was again abolished by TA. TA further showed similar effects to neutralization of VEGFR-1 and VEGFR-2 in inhibiting cell proliferation, migration, invasion and tube formation of HUVECs induced by VEGF165, suggesting that TA could inhibit angiogenesis by targeting VEGFRs in HUVECs. In addition, VEGF165 enhanced the expression of VEGFRs and promoted tyrosine phosphorylation of VEGFR-1 and VEGFR-2 in normal human melanocytes, which were also attenuated by TA. Furthermore, TA showed similar effects to neutralization of VEGFR-1 and VEGFR-2 in inhibiting tyrosinase activity, melanin production and even melanogenic proteins induced by VEGF165, suggesting that TA could reduce melanogenesis via inhibiting activation of VEGFRs and subsequent expression of melanogenic proteins in melanocytes. Taken together, we demonstrate that TA can inhibit angiogenesis and melanogenesis

Indexed as

Angiogenesis InhibitorsCell MovementCell ProliferationHumansHuman Umbilical Vein Endothelial CellsMelaninsMelanocytesMonophenol MonooxygenaseNeuropilin-1Tranexamic AcidVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2Angiogenesis InhibitorsKDR protein, humanMelaninsMonophenol MonooxygenaseNeuropilin-1NRP1 protein, humanTranexamic AcidVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2VEGFA protein, humanangiogenesishuman umbilical vein endothelial cellsmelanocytesmelanogenesistranexamic acidVEGF receptors

Identifiers

PMID32308543
PMCPMC7163366
OpenAlexW3016066853

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.