Evidence map›Paper›PMID 32308542›Full record

ReviewInternational journal of medical sciences2020

Direct-acting Antiviral in the Treatment of Chronic Hepatitis C: Bonuses and Challenges.

Haiyan Zeng, Lei Li, Zhouhua Hou, Yapeng Zhang, Zhongxiang Tang, Shuiping Liu

Abstract readReview
In one paragraph

Review in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  13. [Current status and treatment strategies for liver injury before targeted immunotherapy for liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haiyan ZengDepartment of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.
Lei LiDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Zhouhua HouDepartment of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.
Yapeng ZhangDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Zhongxiang TangDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
Shuiping LiuDepartment of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Owing to the rapid development and wide clinical application of direct acting antiviral (DAA) drugs in the treatment of hepatitis C virus (HCV) infection, the era of interferon-based therapy has almost come to an end. Cumulative studies show that DAA therapy renders high cure efficiency (>90%) and good safety profile, and may even bring some unexpected benefits to the patients. However, some issues of concern arise, one of which is the resistance mutation of HCV genome leading to failure of treatment. With the aim of providing some meaningful references for the treatment of chronic hepatitis C (CHC), this article summarizes the research progress on benefits of DAA accompanied by viral clearance in the treatment of chronic hepatitis and the drug resistance.

Indexed as

Antiviral AgentsDrug Resistance, ViralGlucoseHepacivirusHepatitis C, ChronicHumansLipid MetabolismLiverLiver Function TestsAntiviral AgentsGlucosedirect acting antiviral (DAA)hepatitis C virus (HCV)resistance-associated substitutions (RAS)sustained virological response (SVR)

Identifiers

PMID32308542
PMCPMC7163356

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.