Evidence map›Paper›PMID 32308248›Full record

ArticlePerspectives in medical virology2003

I, 2. Physiology and pathophysiology of the gut in relation to viral diarrhea.

Fabián Michelangeli, Marie Christine Ruiz

Abstract read
In one paragraph

Article in Perspectives in medical virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. LMWP (S3-3) from the Larvae ofMolecules (Basel, Switzerland) · 2022
    Article
  2. Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Fabián MichelangeliLaboratorio de Fisiología Gastrointestinal, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas (IVIC) Caracas, Venezuela.
Marie Christine RuizLaboratorio de Fisiología Gastrointestinal, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas (IVIC) Caracas, Venezuela.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many advances have been made in the understanding of intestinal electrolyte transport from the molecular to the whole-tissue level. This chapter discusses the molecular mechanisms of intestinal epithelial ion transport processes, as well as the intra- and extracellular factors involved in their regulation, as a framework for the understanding of virus-induced gastroenteritis. Based on the present knowledge of the effects of rotavirus (RV) infection on the physiology of the intestine at different levels of organization, a working model for the pathogenesis of RV diarrhea is presented in the chapter. The understanding of the pathogenic processes of viral diarrheas may serve as the basis for a rational approach in the design of novel therapeutic strategies and the search for new antiviral drugs.

Indexed as

5HT, 5-hydroxytryptamine, serotoninAC, adenylate cyclaseACh, acetylcholineAQP, water channels of the aquaporin familyCaCC, Ca2+-activated chloride channelCAMP, adenosine 3′-5′ cyclic monophosphateCF, cystic fibrosisCFTR, cystic fibrosis transmembrane conductance regulator, chloride channelcGMP, guanosine 3′-5′ cyclic monophosphateENS, enteric nervous systemER, endoplasmic reticulumGC, guanylate cyclaseGLUT2, facilitated sugar

Identifiers

PMID32308248
PMCPMC7157931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.