ArticleAmerican journal of physiology. Renal physiology2020
Intradialytic acid-base changes and organic anion production during high versus low bicarbonate hemodialysis.
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Effect of time-dependent dialysate bicarbonate concentrations on acid-base and uremic solute kinetics during hemodialysis treatments.Scientific reports · 2024Trial
- Predictive performance of central venous oxygen saturation, lactate, base excess, and alactic base excess for intradialytic hypotension.BMC nephrology · 2025Observational
- Concurrent Control of Sodium and Bicarbonate Serum Concentrations Using a Four-Stream Hemodialysis Fluid Delivery System.Hemodialysis international. International Symposium on Home Hemodialysis · 2025Article
- Mathematical modelling of bicarbonate supplementation and acid-base chemistry in kidney failure patients on hemodialysis.PloS one · 2023Article
- Replenishing Alkali During Hemodialysis: Physiology-Based Approaches.Kidney medicine · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The use of high dialysate bicarbonate for hemodialysis in end-stage renal disease is associated with increased mortality, but potential physiological mediators are poorly understood. Alkalinization due to high dialysate bicarbonate may stimulate organic acid generation, which could lead to poor outcomes. Using measurements of β-hydroxybutyrate (BHB) and lactate, we quantified organic anion (OA) balance in two single-arm studies comparing high and low bicarbonate prescriptions. In
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.