SynthesisBrain and behavior2020
Gene-disease association study of tumor necrosis factor-α G-308A gene polymorphism with risk of major depressive disorder: A systematic review and meta-analysis.
Synthesis in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 7 citations in OpenAlex.
- Secondary Mania induced by TNF-α inhibitors: A systematic review.Psychiatry and clinical neurosciences · 2022Pooled it
- Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Gene-disease association study of tumor necrosis factor-α G-308A gene polymorphism with risk of major depressive disorder: A systematic review and meta-analysis.Brain and behavior · 2020Pooled it
- Review
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Preliminary investigation of two promoter region polymorphisms of theBiomedical reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe single nucleotide polymorphism (SNP) of the tumor necrosis factor-α (TNF-α) G-308A gene is the most studied regarding susceptibility to major depressive disorder (MDD). However, results have been controversial perhaps due to the heterogeneous genetic backgrounds influenced by race as well as subtypes of depression. METHODS AND MATERIALS: A systematic MEDLINE search was performed to retrieve all published studies that identified the connection between the TNF-α G-308A gene polymorphism and the risk of MDD.
resultsThere was no statistical difference between the allele frequencies or genotypes of TNF-α G-308A gene and the depressive patients or healthy subjects in the five models tested. Further, subgroup analyses showed that the TNF-α G-308A gene polymorphism also did not confer susceptibility to poststroke, late-life, maternal, or major depression. Publication bias analysis showed p values were more than .05, suggesting that the 9 articles included in the current analysis had no publication bias.
conclusionNeither the allele frequencies nor genotypes of TNF-α G-308A gene could be served as an independent risk factor of depression.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.