Evidence map›Paper›PMID 32307732›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

Optical Control of GABA

Karin Rustler, Galyna Maleeva, Alexandre M J Gomila, Pau Gorostiza, Piotr Bregestovski, Burkhard König

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Light-Activated Agonist-Potentiator of GABAJournal of the American Chemical Society · 2024
    Article
  4. Article
  5. Review
  6. Molecular photoswitches in aqueous environments.Chemical Society reviews · 2021
    Review
  7. Review
  8. Optical Control of GABAChemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karin RustlerInstitute of Organic Chemistry, Department of Chemistry and Pharmacy, University of Regensburg, 93053, Regensburg, Germany.ORCID http://orcid.org/0000-0001-6548-1333
Galyna MaleevaINSERM, INS, Institut de Neurosciences des Systèmes, Aix-Marseille University, 13005, Marseille, France.ORCID http://orcid.org/0000-0002-1379-1521
Alexandre M J GomilaInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, 08028, Spain.ORCID http://orcid.org/0000-0003-0867-6171
Pau GorostizaInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, 08028, Spain.ORCID http://orcid.org/0000-0002-7268-5577
Piotr BregestovskiINSERM, INS, Institut de Neurosciences des Systèmes, Aix-Marseille University, 13005, Marseille, France.ORCID http://orcid.org/0000-0003-2699-7825
Burkhard KönigInstitute of Organic Chemistry, Department of Chemistry and Pharmacy, University of Regensburg, 93053, Regensburg, Germany.ORCID http://orcid.org/0000-0002-6131-4850

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1442Bundesministerium für Bildung und ForschungERA SynBIO PCIN-2015-163-C02-01Human Brain Project HBPA SGA3 945539IBEC-BEST GA 712754la Caixa Foundation LCF/PR/HR19/52160010MINECO CTQ2016-80066RRis3CAT-CECH 001-P-001682Russian Science Foundation 18-15-00313Severo Ochoa Program SEV-2014-0425
6 · The paper itself

Abstract

Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ-aminobutyric acid receptors (GABA

Indexed as

Benzodiazepinesgamma-Aminobutyric AcidReceptors, GABA-ABenzodiazepinesgamma-Aminobutyric AcidReceptors, GABA-AfulgimidesGABAA Receptorsin vivophotopharmacology

Identifiers

PMID32307732
PMCPMC7589408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.