ArticleCancer2020
Potential impact of family history-based screening guidelines on the detection of early-onset colorectal cancer.
Article in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- AGA Clinical Practice Update on Risk Stratification for Colorectal Cancer Screening and Post-Polypectomy Surveillance: Expert Review.Gastroenterology · 2023Guideline
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- Metabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers of early-onset colorectal cancer.Discover oncology · 2026Article
- Knowledge, Attitudes, and Perceptions Around Colorectal Cancer Screening and Risk Among 20-49 Year Olds.Digestive diseases and sciences · 2025Article
- Factors associated with late diagnosis of breast cancer among women in Botswana.African journal of primary health care & family medicine · 2025Article
- Listening to patients: A qualitative study on diagnostic delay, coping strategies and stigma in early-onset colorectal cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Advances in Hereditary Colorectal Cancer: How Precision Medicine Is Changing the Game.Cancers · 2025Review
- Review
- Screening the Siblings: Advancing Colon Cancer Prevention by Identifying Advanced Polyps.Digestive diseases and sciences · 2025Article
- Assessment of Knowledge and Barriers to Colon Cancer Screening Among the General Public in the Qassim Region.Cureus · 2025Article
- Prevalence of Screening Colonoscopy among the First-Degree Relatives of Patients with Colorectal Cancer and Related Factors.Middle East journal of digestive diseases · 2025Article
- Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer.Frontiers in immunology · 2025Article
- Article
- Markers of Epithelial-Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- The Usefulness of Vitamin K-Dependent Proteins in the Diagnosis of Colorectal Carcinoma.International journal of molecular sciences · 2024Article
- Review
- The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities.Gut microbes · 2023Review
- Red-flag signs and symptoms for earlier diagnosis of early-onset colorectal cancer.Journal of the National Cancer Institute · 2023Article
- Colorectal Cancer Risk Assessment and Precision Approaches to Screening: Brave New World or Worlds Apart?Gastroenterology · 2023Review
- Comprehensive Analysis of Early-onset Colorectal Cancer: A Review.Journal of the anus, rectum and colon · 2023Review
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 3 countries.
Funding
Abstract
backgroundInitiating screening at an earlier age based on cancer family history is one of the primary recommended strategies for the prevention and detection of early-onset colorectal cancer (EOCRC), but data supporting the effectiveness of this approach are limited. The authors assessed the performance of family history-based guidelines for identifying individuals with EOCRC.
methodsThe authors conducted a population-based, case-control study of individuals aged 40 to 49 years with (2473 individuals) and without (772 individuals) incident CRC in the Colon Cancer Family Registry from 1998 through 2007. They estimated the sensitivity and specificity of family history-based criteria jointly recommended by the American Cancer Society, the US Multi-Society Task Force on CRC, and the American College of Radiology in 2008 for early screening, and the age at which each participant could have been recommended screening initiation if these criteria had been applied.
resultsFamily history-based early screening criteria were met by approximately 25% of cases (614 of 2473 cases) and 10% of controls (74 of 772 controls), with a sensitivity of 25% and a specificity of 90% for identifying EOCRC cases aged 40 to 49 years. Among 614 individuals meeting early screening criteria, 98.4% could have been recommended screening initiation at an age younger than the observed age of diagnosis.
conclusionsOf CRC cases aged 40 to 49 years, 1 in 4 met family history-based early screening criteria, and nearly all cases who met these criteria could have had CRC diagnosed earlier (or possibly even prevented) if earlier screening had been implemented as per family history-based guidelines. Additional strategies are needed to improve the detection and prevention of EOCRC for individuals not meeting family history criteria for early screening.
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Registered trials
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