Evidence map›Paper›PMID 32307589›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2021

Clinical outcomes and thrombus resolution in patients with solid left atrial appendage thrombi: results of a single-center real-world registry.

Dominik Nelles, Moritz Lambers, Myriam Schafigh, Pedro Morais, Robert Schueler, Vivian Vij, Vedat Tiyerili, Marcel Weber, Jan Wilko Schrickel, Georg Nickenig and 2 more

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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  6. Comparison of therapeutic strategies in patients presenting with left atrial thrombus despite oral anticoagulation.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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  15. Anti-thrombotic strategies in patients with atrial fibrillation undergoing PCI.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Dominik NellesMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Moritz LambersElisabeth Krankenhaus, Essen, Germany.
Myriam SchafighKlinik für Herzchirurgie, Herzzentrum Bonn, Bonn, Germany.
Pedro Morais2Ai, Polytechnic Institute of Cávado and Ave, Barcelos, Portugal.
Robert SchuelerElisabeth Krankenhaus, Essen, Germany.
Vivian VijMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Vedat TiyeriliMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Marcel WeberMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Jan Wilko SchrickelMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Georg NickenigMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Christoph HammerstinglMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Alexander SedaghatMed. Klinik Und Poliklinik II, Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany. Alexander.Sedaghat@ukbonn.de.
University Hospital Bonn · DEElisabeth-Krankenhaus Essen · DEDeutsches Herzzentrum der Charité · DEPolytechnic Institute of Cávado and Ave · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData on thrombus resolution and clinical outcome data after a therapy of LAA thrombus with novel oral anticoagulants (NOACs) are scarce.

methodsIn this single-center study, we retrospectively analyzed 78 patients diagnosed with a solid LAA thrombus by transesophageal echocardiography (TEE). We assessed baseline clinical and echocardiographic characteristics, the anticoagulatory regimens and outcomes of patients with (responders) and without (non-responders) thrombus resolution.

resultsMean age was 76.1 ± 8.3 years, patients were male in 57.7% and presented with a high risk for thromboembolism (CHA

conclusionsIn this registry, approximately 85% of LAA thrombi were diagnosed in patients with ongoing OAC. Thrombus resolution was observed in nearly 50% of cases. Although there was no difference in the rate of LAA thrombus resolution between VKA and NOACs, the resolution time was shorter in patients prescribed a NOAC.

Indexed as

RegistriesAdministration, OralAgedAnticoagulantsAtrial AppendageAtrial FibrillationEchocardiography, TransesophagealFemaleFollow-Up StudiesHeart DiseasesHumansMaleRetrospective StudiesThrombosisTreatment OutcomeAnticoagulantsAnticoagulationAtrial fibrillationBleedingLeft atrial appendageNOACThrombusVKA

Identifiers

PMID32307589
OpenAlexW3016568817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.