Evidence map›Paper›PMID 32307322›Full record

SynthesisJournal of the Formosan Medical Association = Taiwan yi zhi2020

Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis.

Tu-Hsuan Chang, Jhong-Lin Wu, Luan-Yin Chang

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the Formosan Medical Association = Taiwan yi zhi, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 13 pooled it
22.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 13 syntheses or guidelines pooled it, 249 citations in OpenAlex.

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  7. Chest CT abnormalities in COVID-19: a systematic review.International journal of medical sciences · 2021
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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Tu-Hsuan ChangChi-Mei Medical Center, Tainan, Taiwan.
Jhong-Lin WuNational Taiwan University Hospital, Taipei, Taiwan.
Luan-Yin ChangNational Taiwan University Hospital, Taipei, Taiwan. Electronic address: lychang@ntu.edu.tw.
National Taiwan University Hospital · TWChi Mei Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background/purposeCurrent studies on pediatric coronavirus disease 2019 (COVID-19) are rare. The clinical characteristics and spectrum are still unknown. Facing this unknown and emerging pathogen, we aimed to collect current evidence about COVID-19 in children.

methodsWe performed a systematic review in PubMed and Embase to find relevant case series. Because some reports were published in Chinese journals, the journals and publications of the Chinese Medical Association related to COVID-19 were completely reviewed. A random effects model was used to pool clinical data in the meta-analysis.

resultsNine case series were included. In the pooled data, most of patients (75%) had a household contact history. The disease severity was mainly mild to moderate (98%). Only 2 children (2%) received intensive care. Fever occurred in 59% of the patients, while cough in 46%. Gastrointestinal symptoms (12%) were uncommon. There are 26% children are asymptomatic. The most common radiographic finding was ground glass opacities (48%). Currently, there is no evidence of vertical transmission to neonates born to mothers with COVID-19. Compared with the most relevant virus, SARS-CoV, SARS-CoV-2 causes less severe disease.

conclusionCOVID-19 has distinct features in children. The disease severity is mild. Current diagnosis is based mainly on typical ground glass opacities on chest CT, epidemiological suspicion and contact tracing.

Indexed as

Clinical Laboratory TechniquesCoronavirusBetacoronavirusChildContact TracingCoronavirus InfectionsCoughCOVID-19COVID-19 TestingFeverHumansLungPandemicsPneumonia, ViralPolymerase Chain ReactionSARS-CoV-2ChildrenCOVID-19SARS-CoV-2

Identifiers

PMID32307322
PMCPMC7161491
OpenAlexW3016746922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.