Evidence map›Paper›PMID 32306970›Full record

ArticleJournal of nanobiotechnology2020

Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage.

Mingxin Li, Guohao Liu, Kaixuan Wang, Lingfeng Wang, Xiang Fu, Lee Yong Lim, Wei Chen, Jingxin Mo

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Microglia-targetedMaterials today. Bio · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Nanobiotechnologies for stroke treatment.Nanomedicine (London, England) · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Dauricine: Review of Pharmacological Activity.Drug design, development and therapy · 2024
    Review
  16. Review
  17. Review
  18. Advances of nanotechnology for intracerebral hemorrhage therapy.Frontiers in bioengineering and biotechnology · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mingxin LiClinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Guohao LiuClinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Kaixuan WangClinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Lingfeng WangClinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Xiang FuDepartment of Pharmacy, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Lee Yong LimDivision of Pharmacy, School of Allied Health, University of Western Australia, Perth, WA, 6009, Australia.
Wei ChenClinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China. daicw1104@163.com.
Jingxin MoClinical Research Center for Neurological Diseases of Guangxi Province, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China. Jingxin.mo@hotmail.com.ORCID http://orcid.org/0000-0002-9574-6037
Guilin Medical University · CNThe University of Western Australia · AU

Funding

Major Project of Guangxi Science and Technology Department AA17292001State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) CMEMR2018-B06the National Natural Science Foundation of China 81860629the Open Funds of the Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation 2018KF003
6 · The paper itself

Abstract

Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, lack of specific targeting to the hemorrhagic site, and poor control of drug release. To exploit the fact that metal ions such as Fe

Indexed as

AnimalsBenzylisoquinolinesBlood-Brain BarrierCalixarenesCerebral HemorrhageDisease Models, AnimalDrug CarriersHumansInterleukin-1betaIonsMaleMatrix Metalloproteinase 9MetalsMiceMice, Inbred C57BLNanostructuresBenzylisoquinolinescalix(4)areneCalixarenesdauricineDrug CarriersInterleukin-1betaIonsMatrix Metalloproteinase 9MetalsNeuroprotective AgentsOrganophosphonatesPhenolsReactive Oxygen SpeciesTetrahydroisoquinolinesApoptosisDauricineFerroptosisIntracerebral hemorrhagePhosphonated calix[4]arene derivativeTargeted delivery

Identifiers

PMID32306970
PMCPMC7168846
OpenAlexW3016535175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.