Evidence map›Paper›PMID 32306924›Full record

ArticleBMC cancer2020

Hospitalization and definitive radiotherapy in lung cancer: incidence, risk factors and survival impact.

Sarah Z Hazell, Nicholas Mai, Wei Fu, Chen Hu, Cole Friedes, Alex Negron, Khinh Ranh Voong, Josephine L Feliciano, Peijin Han, Samantha Myers and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sarah Z HazellDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA.
Nicholas MaiDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA.
Wei FuDepartment of Oncology, Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chen HuDepartment of Oncology, Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cole FriedesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA.
Alex NegronDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA.
Khinh Ranh VoongDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA.
Josephine L FelicianoDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peijin HanDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA.
Samantha MyersDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Todd R McNuttDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA.
Russell K HalesDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 300 Mason Lord Drive, Baltimore, MD, 21224, USA. rhales1@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnplanned hospitalization during cancer treatment is costly, can disrupt treatment, and affect patient quality of life. However, incidence and risks factors for hospitalization during lung cancer radiotherapy are not well characterized.

methodsPatients treated with definitive intent radiation (≥45 Gy) for lung cancer between 2008 and 2018 at a tertiary academic institution were identified. In addition to patient, tumor, and treatment related characteristics, specific baseline frailty markers (Charlson comorbidity index, ECOG, patient reported weight loss, BMI, hemoglobin, creatinine, albumin) were recorded. All cancer-related hospitalizations during or within 30 days of completing radiation were identified. Associations between baseline variables and any hospitalization, number of hospitalizations, and overall survival were identified using multivariable linear regression and multivariable Cox proportional-hazards models, respectively.

resultsOf 270 patients included: median age was 66.6 years (31-88), 50.4% of patients were male (n = 136), 62% were Caucasian (n = 168). Cancer-related hospitalization incidence was 17% (n = 47), of which 21% of patients hospitalized (n = 10/47) had > 1 hospitalization. On multivariable analysis, each 1 g/dL baseline drop in albumin was associated with a 2.4 times higher risk of any hospitalization (95% confidence interval (CI) 1.2-5.0, P = 0.01), and baseline hemoglobin ≤10 was associated with, on average, 2.7 more hospitalizations than having pre-treatment hemoglobin > 10 (95% CI 1.3-5.4, P = 0.01). After controlling for baseline variables, cancer-related hospitalization was associated with 1.8 times increased risk of all-cause death (95% CI: 1.02-3.1, P = 0.04).

conclusionsOur data show baseline factors can predict those who may be at increased risk for hospitalization, which was independently associated with increased mortality. Taken together, these data support the need for developing further studies aimed at early and aggressive interventions to decrease hospitalizations during treatment.

Indexed as

Adenocarcinoma of LungAdultAgedAged, 80 and overCarcinoma, Small CellCarcinoma, Squamous CellFemaleFollow-Up StudiesHospitalizationHumansIncidenceLung NeoplasmsMaleMiddle AgedPrognosisQuality of LifeHospitalizationLung cancerMortalityNomogramRadiation

Identifiers

PMID32306924
PMCPMC7169027
OpenAlexW3017388247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.