Evidence map›Paper›PMID 32306908›Full record

ArticleBMC infectious diseases2020

Molecular diagnosis of autochthonous human anaplasmosis in Austria - an infectious diseases case report.

Wolfgang Hoepler, Mateusz Markowicz, Anna-Margarita Schoetta, Alexander Zoufaly, Gerold Stanek, Christoph Wenisch

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2023
    Article
  2. Review
  3. Article
  4. Article
  5. Ecotyping ofAnimals : an open access journal from MDPI · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wolfgang Hoepler4th Medical Department with Infectious Diseases and Tropical Medicine, Sozialmedizinisches Zentrum Süd - Kaiser-Franz-Josef-Spital mit Gottfried von Preyer'schem Kinderspital, KFJ-Spital, Kundratstrasse 3, 1100, Vienna, Austria. w.hoepler@gmx.at.
Mateusz MarkowiczInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
Anna-Margarita SchoettaInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
Alexander Zoufaly4th Medical Department with Infectious Diseases and Tropical Medicine, Sozialmedizinisches Zentrum Süd - Kaiser-Franz-Josef-Spital mit Gottfried von Preyer'schem Kinderspital, KFJ-Spital, Kundratstrasse 3, 1100, Vienna, Austria.
Gerold StanekInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
Christoph Wenisch4th Medical Department with Infectious Diseases and Tropical Medicine, Sozialmedizinisches Zentrum Süd - Kaiser-Franz-Josef-Spital mit Gottfried von Preyer'schem Kinderspital, KFJ-Spital, Kundratstrasse 3, 1100, Vienna, Austria.
Kaiser-Franz-Josef-Spital · ATMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe diagnosis of human anaplasmosis remains elusive and is probably often missed. This case report highlights the efficacy of molecular diagnostic techniques. CASE PRESENTATION: We would like to report the case of a 74-year-old man who was admitted to hospital because of a high fever, marked chills, transient diplopic images and vertigo, 6 weeks after multiple tick bites. The laboratory results showed mild anemia, marked thrombocytopenia and leukopenia and a moderately elevated C-reactive protein. The initial serology seemed to indicate an active infection with Borrelia spp., and Anaplasma phagocytophilum was detected in peripheral blood by polymerase chain reaction (PCR) and subsequent sequencing. The patient received intravenous ceftriaxone for 14 days and oral doxycycline for 4 weeks and made a fast and complete recovery.

conclusionsWhile human anaplasmosis has been reported very rarely in Austria, it should be considered as a differential diagnosis in febrile patients with low leukocyte and platelet counts with elevated levels of C-reactive protein after exposure to tick bites. Molecular detection of A. phagocytophilum is the technique of choice allowing rapid and reliable diagnosis.

Indexed as

AgedAnaplasma phagocytophilumAnaplasmosisAnimalsAnti-Bacterial AgentsAustriaBorreliaDiagnosis, DifferentialDNA, BacterialHumansMaleMolecular Diagnostic TechniquesTick BitesTreatment OutcomeAnti-Bacterial AgentsDNA, BacterialAnaplasma phagocytophilumInfectious diseasesMolecular diagnosisTick-borne diseases in Western Europe

Identifiers

PMID32306908
PMCPMC7168824
OpenAlexW3017031845

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.