Evidence map›Paper›PMID 32306768›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Acute Effects of Transcatheter Aortic Valve Replacement on Central Aortic Hemodynamics in Patients With Severe Aortic Stenosis.

Michael Michail, Alun D Hughes, Andrea Comella, James N Cameron, Robert P Gooley, Liam M McCormick, Anthony Mathur, Kim H Parker, Adam J Brown, James D Cameron

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07509554 (Investigation of the Relationship Between Changes in Modern Wave-Based Hemodynamic Metrics and Procedural Success or Clinical Improvement in Patients With Severe Aortic Stenosis Following Transcatheter Aortic Valve Replacement), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07509554 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Investigation of the Relationship Between Changes in Modern Wave-Based Hemodynamic Metrics and Procedural Success or Clinical Improvement in Patients With Severe Aortic Stenosis Following Transcatheter Aortic Valve Replacement (TAVR)

Typeobservational_patient_registrySponsorIstanbul Mehmet Akif Ersoy Educational and Training HospitalRan2026 to 2029Enrolled100ConditionsAortic StenosisArmsTranscatheter aortic valve replacement (TAVR / TAVI)
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Research Progress and Clinical Value of Subendocardial Viability Ratio.Journal of the American Heart Association · 2024
    Review
  9. Article
  10. Article
  11. Arterial stiffness in aortic stenosis - complex clinical and prognostic implications.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2022
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Michael MichailFrom the Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia (M.M., A.C., R.G., L.M.M., A.J.B., J.D.C.).
Alun D HughesInstitute of Cardiovascular Science, University College London, United Kingdom (M.M., A.D.H., A.M.).
Andrea ComellaFrom the Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia (M.M., A.C., R.G., L.M.M., A.J.B., J.D.C.).
James N CameronSt George's Hospital Medical School, London, United Kingdom (J.N.C.).
Robert P GooleyFrom the Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia (M.M., A.C., R.G., L.M.M., A.J.B., J.D.C.).
Liam M McCormickFrom the Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia (M.M., A.C., R.G., L.M.M., A.J.B., J.D.C.).
Anthony MathurInstitute of Cardiovascular Science, University College London, United Kingdom (M.M., A.D.H., A.M.).
Kim H ParkerDepartment of Bioengineering, Imperial College, London, United Kingdom (K.M.P.).
Adam J BrownFrom the Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia (M.M., A.C., R.G., L.M.M., A.J.B., J.D.C.).
James D CameronFrom the Monash Cardiovascular Research Centre and MonashHeart, Monash University and Monash Health, Melbourne, Australia (M.M., A.C., R.G., L.M.M., A.J.B., J.D.C.).
Monash Health · AUSt George's Hospital · GBImperial College London · GBQueen Mary University of London · GBUniversity College London · GB

Funding

British Heart Foundation CS/13/1/30327British Heart Foundation CS/15/6/31468British Heart Foundation IG/18/5/33958British Heart Foundation PG/13/6/29934British Heart Foundation PG/15/75/31748British Heart Foundation PG/17/90/33415Medical Research Council MC_UU_12019/1Medical Research Council MR/P023444/1
6 · The paper itself

Abstract

Severe aortic stenosis induces abnormalities in central aortic pressure, with consequent impaired organ and tissue perfusion. Relief of aortic stenosis by transcatheter aortic valve replacement (TAVR) is associated with both a short- and long-term hypertensive response. Counterintuitively, patients who are long-term normotensive post-TAVR have a worsened prognosis compared with patients with hypertension, yet the underlying mechanisms are not understood. We investigated immediate changes in invasively measured left ventricular and central aortic pressure post-TAVR in patients with severe aortic stenosis using aortic reservoir pressure, wave intensity analysis, and indices of aortic function. Fifty-four patients (mean age 83.6±6.2 years, 50.0% female) undergoing TAVR were included. We performed reservoir pressure and wave intensity analysis on invasively acquired pressure waveforms from the ascending aorta and left ventricle immediately pre- and post-TAVR. Following TAVR, there were increases in systolic, diastolic, mean, and pulse aortic pressures (all

Indexed as

AortaAortic Valve StenosisArterial PressureHemodynamicsTranscatheter Aortic Valve ReplacementAged, 80 and overAortic ValveBlood Pressure DeterminationFemaleHumansMalePerioperative PeriodPrognosisPulse Wave AnalysisSeverity of Illness Indexblood pressureperfusionprognosisstenosistranscatheter aortic valve replacement

Identifiers

PMID32306768
PMCPMC7224985
OpenAlexW3016833478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.