Evidence map›Paper›PMID 32306754›Full record

ArticleAnnals of medicine2020

Prospective cohort study of daily alcoholic beverage intake as a potential trigger of headaches among adults with episodic migraine.

Elizabeth Mostofsky, Suzanne M Bertisch, Angeliki Vgontzas, Catherine Buettner, Wenyuan Li, Michael Rueschman, Murray A Mittleman

Open access · bronzeAbstract read
In one paragraph

Article in Annals of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  9. Headache disability, lifestyle factors, health perception, and mental disorder symptoms: a cross-sectional analysis of the 2013 National Health Survey in Brazil.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Elizabeth MostofskyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Suzanne M BertischHarvard Medical School, Boston, MA, USA.
Angeliki VgontzasHarvard Medical School, Boston, MA, USA.
Catherine BuettnerHarvard Medical School, Boston, MA, USA.
Wenyuan LiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Michael RueschmanProgram in Sleep Medicine Epidemiology, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Murray A MittlemanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USCircadian (United States) · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Alcohol and Breast Cancer: Genetic Interactions and Effects on Aromatase Inhibitor TherapyK01AA027831 · NIAAA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MOSTOFSKY, ELIZABETH · 2019 to 2023
$820k
Short Sleep Duration and Sleep Disturbance as a Trigger of MigraineR21NS091627 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI BERTISCH, SUZANNE · 2015 to 2016
$498k
NCATS NIH HHS UL1 TR002541NIAAA NIH HHS K01 AA027831NINDS NIH HHS R21 NS091627
6 · The paper itself

Abstract

purposeTo determine whether alcohol intake is associated with occurrence of headaches on the following day.

methodsIn this prospective cohort study, adults with episodic migraine completed electronic diaries every morning and evening for at least six weeks in March 2016-October 2017. Every day, participants reported alcohol intake, lifestyle factors, and details about each headache. We constructed within-person fixed-effect models adjusted for time-varying factors to calculate odds ratios for the association between 1,2,3,4, or 5+ servings of alcohol and headache the following day. We also calculated the adjusted risk of headache the following day for each level of intake.

resultsAmong 98 participants who reported 825 headaches over 4,467 days, there was a statistically significant linear association (p-trend = 0.03) between alcohol and headache the following day. Compared to no alcohol, 1-2 servings were not associated with headaches, but 5+ servings were associated with a 2.08-fold (95% confidence interval [CI] 1.16-3.73) odds of headache. The adjusted absolute risk of headaches was 20% (95%CI 19%-22%) on days following no alcohol compared with 33% (95%CI 22%-44%) on days following 5+ servings.

conclusion1-2 servings of alcoholic beverages were not associated with higher risk of headaches the following day, but 5+ servings were associated with higher risk. KEY MESSAGES 1-2 servings of alcoholic beverages were not associated with a higher risk of headaches on the following day, but higher levels of intake may be associated with higher risk. Five or more servings were associated with 2.08 times (95% confidence interval 1.16-3.73 the odds of headache on the following day. The adjusted absolute risk of headaches was 20% (95%CI 19%-22%) on days following no alcohol consumption compared with 33% (95% CI 22%-44%) on days following 5+ servings.

Indexed as

AdultAlcohol DrinkingAlcoholic BeveragesAlcohol-Induced DisordersBiological Variation, PopulationCase-Control StudiesCohort StudiesFemaleHeadacheHumansMaleMiddle AgedMigraine DisordersOdds RatioProspective StudiesRisk Assessmentalcoholcase-crossoverCohort studiesheadachemigraine

Identifiers

PMID32306754
PMCPMC7486262
OpenAlexW3017052836

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.