Evidence map›Paper›PMID 32306721›Full record

ArticleIranian biomedical journal2020

Enhanced Adipose Mesenchymal Stem Cells Proliferation by Carboxymethyl-Chitosan Functionalized Polycaprolactone Nanofiber.

Atena Shapourzadeh, Seyed Mohammad Atyabi, Shiva Irani, Hadi Bakhshi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian biomedical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Atena ShapourzadehDepartment of Biochemistry, Faculty of Basic Science, Islamic Azad University Damghan Branch, Damghan, Iran.
Seyed Mohammad AtyabiDepartment of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran 13164, Iran.
Shiva IraniScience and Research Branch, Islamic Azad University, Tehran, Iran.
Hadi BakhshiUniversitatsstraße Bayreuth, Germany-Universitatsstraße Bayreuth, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Through combining two synthetic and natural polymers, scaffolds can be developed for tissue engineering and regenerative medicine purposes. Methods: In this work, carboxymethyl chitosan (CMC; 20%) was grafted to Polycaprolactone (PCL) nanofibers using the cold atmospheric plasma of helium. The PCL scaffolds were exposed to CAP, and functional groups were developed on the PCL surface. Results: The results of Fourier Transform Infrared Spectroscopy confirmed CMC (20%) graft on PCL scaffold. The Thiazolyl blue tetrazolium bromide assay showed a significant enhancement (p < 0.05) in the cell affinity and proliferation of adipose-derived stem cells (ADSCs) to CMC20%-graft-PCL scaffolds. After 14 days, bone differentiation was affirmed through alizarin red and calcium depositions. Conclusion: Based on the results, the CMC20%-graft-PCL can support the proliferation of ADSCs and induce the differentiation into bone with longer culture time.

Indexed as

AnimalsCalciumCell AdhesionCell ProliferationCell SurvivalChitosanHumansMesenchymal Stem CellsNanofibersPlasma GasesPolyestersSpectroscopy, Fourier Transform InfraredCalciumcarboxymethyl-chitosanChitosanPlasma GasespolycaprolactonePolyestersCarboxymethyl chitosanMesenchymal stem cellsTissue engineering

Identifiers

PMID32306721
PMCPMC7275816

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.