Evidence map›Paper›PMID 32306284›Full record

ArticleBiological trace element research2021

In Vivo and In Vitro Assessments of the Antibacterial Potential of Chitosan-Silver Nanocomposite Against Methicillin-Resistant Staphylococcus aureus-Induced Infection in Rats.

Eman I Hassanen, Eman Ragab

Abstract read
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In one paragraph

Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
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  6. Article
  7. Chitosan-LoadedAntioxidants (Basel, Switzerland) · 2024
    Article
  8. Metal copper and silver revealed potent antimicrobial activity for treatingAmerican journal of translational research · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Advances in Nanostructures for Antimicrobial Therapy.Materials (Basel, Switzerland) · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eman I HassanenPathology Department, Faculty of Veterinary Medicine, Cairo University, PO Box 12211, Giza, Egypt.ORCID https://orcid.org/0000-0003-3670-6841
Eman RagabMicrobiology Department, Faculty of Veterinary Medicine, Cairo University, PO Box 12211, Giza, Egypt. eman_ragab2008@cu.edu.eg.ORCID https://orcid.org/0000-0001-7363-2496
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening multidrug-resistant bacteria worldwide. Owing to their efficient antimicrobial properties, nanoparticles have been widely used as an alternative approach for combating the antibiotic-resistant bacteria. Consequently, this study was designed to compare in between the bactericidal effect of low doses (5 mg/kg bwt) of nanoparticles of chitosan (Ch-NPs), silver (Ag-NPs), and chitosan-silver nanocomposites (Ch-Ag NCs) both in vitro and in vivo against experimentally chronic infection induced by methicillin-resistant Staphylococcus aureus (MRSA). The three forms of nanoparticles were tested for their in vitro antimicrobial potential against MRSA by detection of MICs and MBCs using microdilution method. In vivo, thirty-five male albino Wistar rats were used and divided into five groups (n = 7). Group l (negative control), group 2 (MRSA infected and untreated), groups 3, 4, and 5 (MRSA infected then treated with Ch-NPs, Ag-NPs, and Ch-Ag NCs respectively for 7 days). After 6 weeks, blood samples were collected then rats were euthanized to collect different organs (liver, spleen, lungs, and kidneys). Some of them were kept in 10% formalin for histopathological investigations while others used for bacterial re-isolation. Ch-Ag NCs showed the lowest MIC and MBC among the tested nanoparticles. Moreover, the highest histopathological scoring was observed in the infected and untreated group while the lowest scoring was detected in groups treated with Ch-Ag NCs in comparison with the negative control group. The highest bacterial count was noticed in the infected and untreated group followed by those treated with Ch-NPs while the lowest count was observed in group treated with Ch-Ag NCs. Depending on these results, it can be concluded that Ch-Ag NCs have a strong bactericidal effect against MRSA and may be used as alternative option to antibiotics.

Indexed as

ChitosanMetal NanoparticlesMethicillin-Resistant Staphylococcus aureusNanocompositesAnimalsAnti-Bacterial AgentsMaleMicrobial Sensitivity TestsRatsSilverAnti-Bacterial AgentsChitosanSilverChitosan-silverHistopathologyMRSANanoparticlesRats

Identifiers

PMID32306284
OpenAlexW3016791011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.