Evidence map›Paper›PMID 32306273›Full record

Observational studyUpdates in surgery2020

Delayed surgery after radio-chemotherapy for rectal adenocarcinoma is protective for anastomotic dehiscence: a single-center observational retrospective cohort study.

Damiano Caputo, Silvia Angeletti, Michele Fiore, Massimo Ciccozzi, Alessandro Coppola, Mariacristina Cartillone, Vincenzo La Vaccara, Giuseppe Spagnolo, Lucio Trodella, Roberto Coppola

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Updates in surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04013347 (Evaluation of Anatomopathological, Oncological and Surgical Outcomes in Relation to the Different Times Between the End of Neoadjuvant Treatment and Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04013347 completednot on this map

Evaluation of Anatomopathological, Oncological and Surgical Outcomes in Relation to the Different Times Between the End of Neoadjuvant Treatment and Surgery

TypeobservationalSponsorCampus Bio-Medico UniversityRan2005 to 2017Enrolled167ConditionsNeoadjuvant Chemoradiotherapy, Rectal Tumor, Surgery, Surgery--ComplicationsArmsRectal Resection
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Damiano CaputoDepartment of Surgery, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy. d.caputo@unicampus.it.
Silvia AngelettiUnit of Clinical Laboratory Science, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy.
Michele FioreRadiation Oncology, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200,, 00128, Rome, Italy.
Massimo CiccozziUnit of Medical Statistic and Molecular Epidemiology, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy.
Alessandro CoppolaGeneral Surgery and Liver Transplant Unit Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy.
Mariacristina CartilloneDepartment of Surgery, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy.
Vincenzo La VaccaraDepartment of Surgery, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy.
Giuseppe SpagnoloDepartment of Surgery, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy.
Lucio Trodella, Largo Agostino Gemelli, 8, 00168, Rome, Italy.
Roberto CoppolaDepartment of Surgery, University Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 200, 00128, Rome, Italy.
Università Campus Bio-Medico · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ideal time interval between end of neoadjuvant radio-chemotherapy (NRCT) and surgery for rectal cancer is debated. Effect that different time intervals have on postoperative complications with particular regard to anastomotic dehiscence (AD) was evaluated on 167 patients who underwent surgery after long-course NRCT. Three different time intervals were considered: (0-42; 43-56; > 57 days). A time interval > 57 days was significantly protective for AD (p = 0.04, Odds ratio = 0.35; 95% CI 0.1254-0.9585) without influence on early oncological outcomes. Optimal time interval after end of NRCT and surgery may help achieving the best pathological response with lowest postoperative morbidity.Trial registration number: Clinical Trial. Gov NCT04013347. https://clinicaltrials.gov/ct2/results?cond=&term=NCT04013347&cntry=&state=&city=&dist= ).

Indexed as

Chemoradiotherapy, AdjuvantNeoadjuvant TherapyTime-to-TreatmentAdenocarcinomaAdultAgedAged, 80 and overAnastomosis, SurgicalCohort StudiesDigestive System Surgical ProceduresFemaleHumansMaleMiddle AgedMorbidityPostoperative ComplicationsDelayed surgeryNeoadjuvantRectal cancer surgeryTiming

Identifiers

PMID32306273
OpenAlexW3016501401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.