ArticlePlanta2020
Multi-targeted trehalose-6-phosphate phosphatase I harbors a novel peroxisomal targeting signal 1 and is essential for flowering and development.
Article in Planta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trehalose-6-Phosphate Phosphatase I (TPPI) Regulates Floral Transition, Nitrogen Responses, and Photosynthetic Performance in Arabidopsis.Plants (Basel, Switzerland) · 2026Article
- Genome-Wide Analysis of Trehalose-6-Phosphate Phosphatases (TPP) Gene Family in Potato (Plants (Basel, Switzerland) · 2025Article
- The role of trehalose metabolism in plant stress tolerance.Journal of advanced research · 2025Review
- Article
- TheMolecular breeding : new strategies in plant improvement · 2024Article
- A spatial transcriptome map of the developing maize ear.Nature plants · 2024Article
- Flowering genes identification, network analysis, and database construction for 837 plants.Horticulture research · 2024Article
- Genome-Wide Identification and Expression Analysis of the Trehalose-6-phosphate Synthase and Trehalose-6-phosphate Phosphatase Gene Families in Rose (Plants (Basel, Switzerland) · 2023Article
- Genome- and transcriptome-wide identification of trehalose-6-phosphate phosphatases (TPP) gene family and their expression patterns under abiotic stress and exogenous trehalose in soybean.BMC plant biology · 2023Article
- Protein-Protein Interactions and Quantitative Phosphoproteomic Analysis Reveal Potential Mitochondrial Substrates of Protein Phosphatase 2A-B'ζ Holoenzyme.Plants (Basel, Switzerland) · 2023Article
- Two trehalase isoforms, produced from a single transcript, regulate drought stress tolerance in Arabidopsis thaliana.Plant molecular biology · 2022Article
- Identification of Arabidopsis Protein Kinases That Harbor Functional Type 1 Peroxisomal Targeting Signals.Frontiers in cell and developmental biology · 2022Article
- Nitric Oxide (NO) Scaffolds the Peroxisomal Protein-Protein Interaction Network in Higher Plants.International journal of molecular sciences · 2021Review
- Convergence and Divergence of Sugar and Cytokinin Signaling in Plant Development.International journal of molecular sciences · 2021Review
- Morphological, Physiological, and Molecular Responses of Sweetly FragrantFrontiers in plant science · 2021Article
- Trehalose Promotes the Melon Seedlings Growth by Mediating Crosstalk of IAA and GA Signalling Pathways.Physiologia plantarumArticle
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Authors and funding
6 authors.
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Abstract
MAIN
conclusionThis work reveals information about new peroxisomal targeting signals type 1 and identifies trehalose-6-phosphate phosphatase I as multitargeted and is implicated in plant development, reproduction, and stress response. A putative, non-canonical peroxisomal targeting signal type 1 (PTS1) Pro-Arg-Met > was identified in the extreme C-terminus of trehalose-6-phosphate phosphatase (TPP)I. TPP catalyzes the final step of trehalose synthesis, and the enzyme was previously characterized to be nuclear only (Krasensky et al. in Antioxid Redox Signal 21(9):1289-1304, 2014). Here we show that the TPPI C-terminal decapeptide ending with Pro-Arg-Met > or Pro-Lys-Met > can indeed function as a PTS1. Upon transient expression in two plant expression systems, the free C- or N-terminal end led to the full-length TPPI targeting to peroxisomes and plastids, respectively. The nucleus and nucleolus targeting of the full-length TPPI was observed in both cases. The homozygous T-DNA insertion line of TPPI showed a pleiotropic phenotype including smaller leaves, shorter roots, delayed flowering, hypersensitivity to salt, and a sucrose dependent seedling development. Our results identify novel PTS1s, and TPPI as a protein multi-targeted to peroxisomes, plastids, nucleus, and nucleolus. Altogether our findings implicate an essential role for TPPI in development, reproduction, and cell signaling.
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