ArticleCerebral cortex (New York, N.Y. : 1991)2020
Heterogeneity in Brain Microstructural Development Following Preterm Birth.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 80 citations in OpenAlex.
- Frequency-specific gyro-sulcal functional differentiation in preterm neonates: Sulcal dominance and gene expression correlates.Developmental cognitive neuroscience · 2026Article
- Early development of cortical networks is modulated by Family Nurture Intervention: a multicenter replication study.Pediatric research · 2026Article
- Understanding the challenges: preterm birth and middle childhood psychomotor skills - a case control study.BMC pediatrics · 2026Observational
- The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.Frontiers in pediatrics · 2026Article
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- Edge participation coefficient unveiling the developmental dynamics of neonatal functional connectome.Communications biology · 2025Article
- Heterogeneous, temporally consistent, and plastic brain development after preterm birth.Nature communications · 2025Article
- Foetal cortical expansion is associated with neurodevelopmental outcome at 2-years in congenital heart disease: a longitudinal follow-up study.EBioMedicine · 2025Article
- Abnormal Local Cortical Functional Connectivity due to Interneuron Dysmaturation after Neonatal Intermittent Hypoxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Characterizing the temporal dynamics and maturation of brain activity during sleep: An EEG microstate study in preterm and full-term infants.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Advances in fetal and neonatal neuroimaging and everyday exposures.Pediatric research · 2024Review
- The correlation between brain structure characteristics and emotion regulation ability in children at high risk of autism spectrum disorder.European child & adolescent psychiatry · 2024Article
- Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3-10 years in China.Scientific data · 2024Article
- Feature similarity gradients detect alterations in the neonatal cortex associated with preterm birth.Human brain mapping · 2024Article
- Preterm-birth alters the development of nodal clustering and neural connection pattern in brain structural network at term-equivalent age.Human brain mapping · 2023Article
- [Recent research on the long-term neurodevelopmental outcomes of very preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- Encoding of continuous perceptual choices in human early visual cortex.Frontiers in human neuroscience · 2023Article
- Deviations from normative brain white and gray matter structure are associated with psychopathology in youth.Developmental cognitive neuroscience · 2022Article
Corrections and comments
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Authors and funding
24 authors at 3 institutions in 4 countries.
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Abstract
Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses of magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity of cerebral injury within the preterm group. This study aimed to determine whether atypical brain microstructural development following preterm birth is significantly variable between infants. Using Gaussian process regression, a technique that allows a single-individual inference, we characterized typical variation of brain microstructure using maps of fractional anisotropy and mean diffusivity in a sample of 270 term-born neonates. Then, we compared 82 preterm infants to these normative values to identify brain regions with atypical microstructure and relate observed deviations to degree of prematurity and neurocognition at 18 months. Preterm infants showed strikingly heterogeneous deviations from typical development, with little spatial overlap between infants. Greater and more extensive deviations, captured by a whole brain atypicality index, were associated with more extreme prematurity and predicted poorer cognitive and language abilities at 18 months. Brain microstructural development after preterm birth is highly variable between individual infants. This poorly understood heterogeneity likely relates to both the etiology and prognosis of brain injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.