ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Poor Oral Health and Inflammatory, Hemostatic, and Cardiac Biomarkers in Older Age: Results From Two Studies in the UK and USA.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association between Dental and Cardiovascular Diseases: A Systematic Review.Reviews in cardiovascular medicine · 2023Pooled it
- Oral virome in health and disease.Journal of the American Dental Association (1939) · 2026Review
- Tooth loss is associated with subsequent brain white matter degradation up to over a decade.Journal of dentistry · 2026Article
- Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Tooth loss progression and mortality among older adults: results from the Chinese longitudinal healthy longevity survey (CLHLS).BMC geriatrics · 2025Article
- Association of participant reported oral health, tooth loss, interdental cleaning and dental visits with serum CRP.Scientific reports · 2025Article
- Association between the number of teeth and all-cause mortality rate in the MASHAD Cohort Study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Severe Tooth Loss and Cardiovascular Disease Among Older Adults in Hawai'i: A Cross-Sectional Study of Behavioral Risk Factor Surveillance System Data from 2012 to 2020.Hawai'i journal of health & social welfare · 2025Article
- Tooth loss and mortality risk: the mediating role of hs-CRP in a Chinese cohort.Frontiers in oral health · 2025Article
- Impact of tooth loss and patient characteristics on coronary artery calcium score classification and prediction.Scientific reports · 2024Article
- Association between Oral Health and Depressive Symptoms in Chinese Older Adults: The Mediating Role of Dietary Diversity.Nutrients · 2024Article
- Oral Health and Its Associated Factors Among the Elderly in the Emergency Department: A Latent Class Analysis.Journal of multidisciplinary healthcare · 2024Article
- Cohort Profile Update: The British Regional Heart Study 1978-2018: 40 years of follow-up of older British men.International journal of epidemiology · 2023Article
- Oral health-related quality of life and oral hygiene status among special need school students in amhara region, Ethiopia.Health and quality of life outcomes · 2023Article
- Tooth loss, denture use, and all-cause and cause-specific mortality in older adults: a community cohort study.Frontiers in public health · 2023Article
- Oral Health, Diabetes, and Inflammation: Effects of Oral Hygiene Behaviour.International dental journal · 2022Article
- Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
- Oral health problems and risk of incident disability in two studies of older adults in the United Kingdom and the United States.Journal of the American Geriatrics Society · 2022Article
- Antibacterial Activity of Silver and Gold Particles Formed on Titania Thin Films.Nanomaterials (Basel, Switzerland) · 2022Article
- Frailty, aging, and periodontal disease: Basic biologic considerations.Periodontology 2000 · 2021Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundWe examined the association of objective and subjective oral health markers with inflammatory, hemostatic, and cardiac biomarkers in older age.
methodsCross-sectional analyses were based on the British Regional Heart Study (BRHS) comprising British men aged 71-92 years (n = 2,147), and the Health, Aging and Body Composition (HABC) Study comprising American men and women aged 71-80 years (n = 3,075). Oral health markers included periodontal disease, tooth count, dry mouth. Inflammatory biomarkers included C-reactive protein (CRP), interleukin-6 (IL-6) in both studies, and tissue plasminogen activator (t-PA), von Willebrand Factor (vWF), fibrin D-dimer, high-sensitivity Troponin T (hsTnT), and N-terminal pro-brain natriuretic peptide (NTproBNP) only in the BRHS.
resultsIn both studies, tooth loss, was associated with the top tertile of CRP-odds ratios (ORs) (95% confidence interval [CI]) are 1.31 (1.02-1.68) in BRHS; and 1.40 (1.13-1.75) in the HABC Study, after adjusting for confounders. In the HABC Study, cumulative (≥3) oral health problems were associated with higher levels of CRP (OR [95% CI] =1.42 [1.01-1.99]). In the BRHS, complete and partial tooth loss was associated with hemostatic factors, in particular with the top tertile of fibrin D-dimer (OR [95% CI] = 1.64 [1.16-2.30] and 1.37 [1.05-1.77], respectively). Tooth loss and periodontal disease were associated with increased levels of hsTnT.
conclusionsPoor oral health in older age, particularly tooth loss, was consistently associated with some inflammatory, hemostatic, and cardiac biomarkers. Prospective studies and intervention trials could help understand better if poor oral health is causally linked to inflammatory, hemostatic, and cardiac biomarkers.
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