ArticleInternational journal of epidemiology2020
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 6 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.Molecular psychiatry · 2026Pooled it
- Epidemiological linkage between migraine and diabetes mellitus: a systematic review and meta-analysis.The journal of headache and pain · 2024Pooled it
- Migraine, chronic kidney disease and kidney function: observational and genetic analyses.Human genetics · 2023Pooled it
- Genetic Overlap Analysis Identifies a Shared Etiology between Migraine and Headache with Type 2 Diabetes.Genes · 2022Pooled it
- Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.Nature genetics · 2022Pooled it
- Phenotypic and Genotypic Associations Between Migraine and Lipoprotein Subfractions.Neurology · 2021Pooled it
- Nomogram for Postoperative Headache in Adult Patients Undergoing Elective Cardiac Surgery.Journal of the American Heart Association · 2022Trial
- Episodic migraine is associated with a more atherogenic lipid profile rather than independent insulin resistance: a case-control study.Lipids in health and disease · 2026Article
- Decoding the lipid-migraine link: a genetic and lipidomic investigation of migraine subtypes.Journal of oral & facial pain and headache · 2026Article
- The relationship between triglyceride levels and medication overuse headache in patients with chronic migraine.Journal of oral & facial pain and headache · 2026Article
- The Association Between Migraine and Type 2 Diabetes Mellitus: A Narrative Review.International journal of preventive medicine · 2026Review
- Migraine and stroke: correlation, coexistence, dependence - a modern perspective.The journal of headache and pain · 2025Review
- Mendelian randomization analysis reveals causal effects of migraine and its subtypes on early-onset ischemic stroke risk.Scientific reports · 2024Article
- Association between severe headache or migraine and lipid accumulation product and visceral adiposity index in adults: a cross-sectional study from NHANES.Lipids in health and disease · 2024Article
- Comprehensive analysis of genetic associations and single-cell expression profiles reveals potential links between migraine and multiple diseases: a phenome-wide association study.Frontiers in neurology · 2024Article
- Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study.Frontiers in genetics · 2024Article
- Investigating the Shared Genetic Etiology Between Parkinson's Disease and Depression.Journal of Parkinson's disease · 2024Article
- Assessing the association between age at first sexual intercourse and migraine: a Mendelian randomization study.Frontiers in neurology · 2024Article
- Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.The journal of headache and pain · 2023Article
- Shared molecular genetic factors influence subcortical brain morphometry and Parkinson's disease risk.NPJ Parkinson's disease · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 18 institutions in 14 countries.
Funding
Abstract
backgroundNearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized.
methodsTo further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available.
resultsWe report multiple phenotypes with genetic correlation (P < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine.
conclusionsThis is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci.
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