Evidence map›Paper›PMID 32306023›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2020

[Effect of convection enhanced delivery on the microstructure of brain extracellular space in aged rats].

Y Song, H B Han, J Yang, A B Wang, Q Y He, Y Y Li, G M Zhao, Y J Gao, R Wang, Y X Han and 2 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Y SongDepartment of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.
H B HanInstitute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
J YangDepartment of Neurosurgery, Peking University Third Hospital, Beijing 100191, China.
A B WangBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Q Y HeBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Y Y LiBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
G M ZhaoBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Y J GaoBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
R WangBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Y X HanBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
A L LiuDepartment of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.
Q W SongDepartment of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China.
Peking University · CNPeking University Third Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the changes of extracellular space (ECS) structure and local drug distribution in adult brain and aged brain at different drug delivery rates in minimally invasive treatment of encephalopathy by convection enhanced delivery (CED) via ECS pathway.

methodsThirty-six SD male rats were divided into adult rats group (2-8 months, n=18) and aged rats group (18-24 months, n=18) according to the age of the month. According to the drug rates (0.1 μL/min, 0.2 μL/min, and 0.3 μL/min), they were randomly divided into 3 subgroups, 6 in each subgroup. Gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) with a concentration of 10 mmol/L were introduced into the caudate nucleus of each group of rats by stereotactic injection. Tracer-based magnetic resonance imaging (MRI) was used to dynamically monitor the diffusion and distribution images of the Gd-DTPA in the brain interstitial system (ISS). Using the self-developed MRI image measurement and analysis system software to process and analyze the obtained images, the diffusion coefficient, clearance rate, volume fraction, and half-life of each group of rats in the caudate nucleus ECS could be acquired. The effects and differences of drug clearance and ECS structural function in the brain of aged rats and adult rats were compared and analyzed at different drug delivery rates. Magnetic tracer D

resultsAt the injection rate of 0.1 μL/min, the volume fraction in the aged rats was increased compared with that in the adult rats (18.20%±0.04% vs. 17.20%±0.03%, t=3.752, P=0.004), and the degree of tortuosity was decreased (1.63±0.04 vs. 1.78±0.09, t=-3.680, P=0.004), the drug clearance rate was decreased [(1.94±0.68) mm

conclusionThe drug clearance and ECS structural parameters of brain ECS in aged brain with CED administration were changed at different rates, and it has the least effect on ECS in the aged brain at the injection rate of 0.2 μL/min. For the application of CED for the treatment of encephalopathy, we should consider the influence of factors such as age and injection rate, and provide reference for the development of individualized clinical treatment plan for minimally invasive treatment of encephalopathy via ECS pathway.

Indexed as

ConvectionExtracellular SpaceAnimalsBrainGadolinium DTPAMagnetic Resonance ImagingMaleRatsRats, Sprague-DawleyGadolinium DTPA

Identifiers

PMID32306023
PMCPMC7433439
OpenAlexW3017322695

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.