Evidence map›Paper›PMID 32305911›Full record

ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2020

Deep Learning of Spatiotemporal Filtering for Fast Super-Resolution Ultrasound Imaging.

Katherine G Brown, Debabrata Ghosh, Kenneth Hoyt

Abstract read
In one paragraph

Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Advancements in Three-Dimensional Super-Resolution Ultrasound Imaging: A Narrative Review.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  3. Article
  4. Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  5. Super-Resolution Ultrasound Imaging for Monitoring the Therapeutic Efficacy of a Vascular Disrupting Agent in an Animal Model of Breast Cancer.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024
    Article
  6. Article
  7. Article
  8. Super-resolution of 2D ultrasound images and videos.Medical & biological engineering & computing · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Deep Learning-Based Microbubble Localization for Ultrasound Localization Microscopy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022
    Article
  14. Evaluation of Nonlinear Contrast Pulse Sequencing for Use in Super-Resolution Ultrasound Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  15. Article
  16. Article
  17. 3-D Super-Resolution Ultrasound Imaging for Monitoring Early Changes in Breast Cancer after Treatment with a Vascular-Disrupting Agent.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2021
    Article
  18. Article
  19. Review
  20. Faster motion correction of clinical contrast-enhanced ultrasound imaging using deep learning.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katherine G Brown
Debabrata Ghosh
Kenneth Hoyt

Funding

Multiparametric ultrasound imaging for early detection of nonalcoholic fatty liver diseaseR01DK126833 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI HOYT, KENNETH · 2021 to 2024
$1.6M
3D Super-Resolution Ultrasound Imaging for Cancer Detection and Treatment MonitoringR01EB025841 · NIBIB · UNIVERSITY OF TEXAS DALLAS · PI HOYT, KENNETH · 2019 to 2022
$1.3M
NIBIB NIH HHS R01 EB025841NIDDK NIH HHS R01 DK126833
6 · The paper itself

Abstract

Super-resolution ultrasound (SR-US) imaging is a new technique that breaks the diffraction limit and allows visualization of microvascular structures down to tens of micrometers. The image processing methods for the spatiotemporal filtering needed in SR-US, such as singular value decomposition (SVD), are computationally burdensome and performed offline. Deep learning has been applied to many biomedical imaging problems, and trained neural networks have been shown to process an image in milliseconds. The goal of this study was to evaluate the effectiveness of deep learning to realize a spatiotemporal filter in the context of SR-US processing. A 3-D convolutional neural network (3DCNN) was trained on in vitro and in vivo data sets using SVD as ground truth in tissue clutter reduction. In vitro data were obtained from a tissue-mimicking flow phantom, and in vivo data were collected from murine tumors of breast cancer. Three training techniques were studied: training with in vitro data sets, training with in vivo data sets, and transfer learning with initial training on in vitro data sets followed by fine-tuning with in vivo data sets. The neural network trained with in vitro data sets followed by fine-tuning with in vivo data sets had the highest accuracy at 88.0%. The SR-US images produced with deep learning allowed visualization of vessels as small as [Formula: see text] in diameter, which is below the diffraction limit (wavelength of [Formula: see text] at 14 MHz). The performance of the 3DCNN was encouraging for real-time SR-US imaging with an average processing frame rate for in vivo data of 51 Hz with GPU acceleration.

Indexed as

Deep LearningSignal Processing, Computer-AssistedAnimalsCell Line, TumorContrast MediaFemaleImage Processing, Computer-AssistedMammary Neoplasms, ExperimentalMiceMice, NudeMicrobubblesNeural Networks, ComputerUltrasonographyContrast Media

Identifiers

PMID32305911
PMCPMC7523282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.