Evidence map›Paper›PMID 32305831›Full record

ArticleEuropean journal of cancer (Oxford, England : 1990)2020

Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.

Ondrej Hrusak, Tomas Kalina, Joshua Wolf, Adriana Balduzzi, Massimo Provenzi, Carmelo Rizzari, Susana Rives, María Del Pozo Carlavilla, Maria E V Alonso, Nerea Domínguez-Pinilla and 31 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of cancer (Oxford, England : 1990), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 8 syntheses or guidelines pooled it, 196 citations in OpenAlex.

  1. Pooled it
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  4. Guideline
  5. Exploring the Impact of COVID-19 on Mental Health Outcomes in Children and Adolescents: A Systematic Review.International journal of environmental research and public health · 2020
    Pooled it
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  8. Pooled it
  9. Clinical Outcomes of Pediatric Cancer Patients with COVID-19: A Cross-Sectional Study.International journal of hematology-oncology and stem cell research · 2024
    Article
  10. Review
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  13. COVID-19 in Children: Molecular Profile and Pathological Features.International journal of molecular sciences · 2023
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 25 countries.

Ondrej HrusakCLIP - Childhood Leukaemia Investigation Prague, Czech Republic; Department of Pediatric Hematology, Charles University and Univ. Hospital Motol, Prague, Czech Republic. Electronic address: Ondrej.Hrusak@lfmotol.cuni.cz.
Tomas KalinaCLIP - Childhood Leukaemia Investigation Prague, Czech Republic; Department of Pediatric Hematology, Charles University and Univ. Hospital Motol, Prague, Czech Republic.
Joshua WolfDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Adriana BalduzziClinica Pediatrica Universita degli Studi di Milano Bicocca, Monza, Italy.
Massimo ProvenziOncologia Pediatrica, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Carmelo RizzariPediatric Hematology Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, ASST Monza, Italy.
Susana RivesHospital Sant Joan de Déu de Barcelona, Spain.
María Del Pozo CarlavillaHospital General Universitario de Albacete, Spain.
Maria E V AlonsoHospital General Universitario de Albacete, Spain.
Nerea Domínguez-PinillaHospital Virgen de la Salud, Spain.
Jean-Pierre BourquinDepartment of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Kjeld SchmiegelowDepartment of Peadiatrics and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen, Denmark.
Andishe AttarbaschiDepartment of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.
Pernilla GrillnerPediatric Oncology, Karolinska University Hospital, Sweden.
Karin MellgrenDepartment of Pediatric Haematology and Oncology, Sahlgrenska University Hospital, Gothenberg, Sweden.
Jutte van der Werff Ten BoschUZ Brussels, Belgium.
Rob PietersPrincess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
Triantafyllia BrozouDepartment of Pediatric Oncology Hematology and Clinical Immunology Heinrich Heine University Dusseldorf.
Arndt BorkhardtDepartment of Pediatric Oncology Hematology and Clinical Immunology Heinrich Heine University Dusseldorf.
Gabriele EscherichKlinik für Pädiatrische Hämatologie und Onkologie Universtitätsklinikum Eppendorf, Hamburg, Germany.
Melchior LautenUniversity Hospital Schleswig-Holstein, Campus Lübeck, Germany.
Martin StanullaDepartment of Pediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany.
Owen SmithNational Children's Cancer Service, Children's Health Ireland at Crumlin, Dublin, Ireland.
Allen E J YeohYong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore.
Sarah ElitzurSchneider Children's Medical Center of Israel.
Ajay VoraGreat Ormond Street Hospital, London, UK.
Chi-Kong LiDepartment of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Hany AriffinUniversity of Malaya Medical Centre, Kuala Lumpur, Malaysia.
Alexandra KolenovaDepartment of Pediatric Hematology and Oncology, Comenius University, Bratislava, Slovakia.
Luciano DallapozzaThe Cancer Centre for Children, The Children's Hospital at Westmead, Australia.
Roula FarahLAUMC-Rizk Hospital, Beirut, Lebanon.
Jelena LazicUniversity Children`s Hospital, Belgrade, Serbia.
Atsushi ManabeHokkaido University in Hospital, Sapporo, Japan.
Jan StyczynskiDepartment of Pediatric Hematology and Oncology, Nicolaus Copernicus University, Bydgoszcz, Poland.
Gabor Kovacs2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary.
Gabor OttoffyOncohematology Unit, Dep. of Ped., University of Pécs, Hungary.
Maria S FeliceHospital de Pediatría, "Prof. Dr. Juan P. Garrahan", Argentina.
Barbara BuldiniOnco Hematology Unit, Dept. Salute della Donna e del Bambino, Università degli Studi di Padova, Italy.
Valentino ConterClinica Pediatrica Universita degli Studi di Milano Bicocca, Monza, Italy.
Jan StaryDepartment of Pediatric Hematology, Charles University and Univ. Hospital Motol, Prague, Czech Republic.
Martin SchrappeChildrens Hospital Medical Center Schleswig-Holstein, Kiel, Germany.
Charles University · CZUniversity of Milano-Bicocca · ITHeinrich Heine University Düsseldorf · DEHospital General Universitario de Albacete · ESUniversity Hospital Schleswig-Holstein · DEChildren's Health Ireland at Crumlin · IEChildren's Hospital at Westmead · AUChinese University of Hong Kong · HKComenius University Bratislava · SKEppendorf (Germany) · DEGarrahan Hospital · ARGreat Ormond Street Hospital · GBHokkaido University Hospital · JPHospital Sant Joan de Déu Barcelona · ESHospital Virgen de la Salud · ESKarolinska University Hospital · SEMedizinische Hochschule Hannover · DENational University of Singapore · SGNicolaus Copernicus University · PLOspedale Papa Giovanni XXIII · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSince the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia. AIM AND

methodsWe made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.

resultsWe received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.

conclusionThus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.

Indexed as

BetacoronavirusAdolescentAntineoplastic AgentsChildCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentFemaleHumansMaleNeoplasmsPandemicsPneumonia, ViralSARS-CoV-2Surveys and QuestionnairesAntineoplastic AgentsAnticancer chemotherapyChildrenCOVID-19Immunosuppression

Identifiers

PMID32305831
PMCPMC7141482
OpenAlexW3016005709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.