Evidence map›Paper›PMID 32305740›Full record

ArticleThrombosis research2020

Severe COVID-19 infection associated with endothelial activation.

Robert Escher, Neal Breakey, Bernhard Lämmle

2 registry-linked trialsAbstract readCase ReportsLetter
In one paragraph

Article in Thrombosis research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 246 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04466670 phase2unknown statusnot on this map

Dynamics of Hemostatic Parameters in COVID-19 and Comparison of Intervention Strategies Through Adaptive Clinical Trial

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2020 to 2022Enrolled379ConditionsCOVID-19Armsacetylsalicylic acid, Unfractionated heparin nebulized
NCT04492254 phase3terminatednot on this map

Early Thromboprophylaxis in COVID-19 (ETHIC Trial): an Open Label, Randomized Phase IIIb Trial of Community-based (LMWH) Versus Standard of Care (no Enoxaparin) in COVID-19 Positive Patients

TypeinterventionalSponsorThrombosis Research InstituteRan2020 to 2021Enrolled219ConditionsCOVID-19ArmsEnoxaparin
3 · Its place in the literature

Who cites it

246 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Guideline
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  16. Deep insight into cytokine storm: from pathogenesis to treatment.Signal transduction and targeted therapy · 2025
    Review
  17. Review
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  19. Observational
  20. Review

186 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Robert EscherDepartment of Medicine, Spital Emmental, Burgdorf, Switzerland.
Neal BreakeyDepartment of Medicine, Spital Emmental, Burgdorf, Switzerland. Electronic address: neal.breakey@spital-emmental.ch.
Bernhard LämmleDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany; Haemostasis Research Unit, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAntibodies, AntiphospholipidAnticoagulantsBetacoronavirusBlood CoagulationCoronavirus InfectionsCOVID-19DalteparinEndotheliumFactor VIIIFibrin Fibrinogen Degradation ProductsHeparinHumansImmunoglobulin MIntensive Care UnitsMaleAntibodies, AntiphospholipidAnticoagulantsDalteparinFactor VIIIFibrin Fibrinogen Degradation Productsfibrin fragment DHeparinImmunoglobulin Mvon Willebrand Factor

Identifiers

PMID32305740
PMCPMC7156948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.