Evidence map›Paper›PMID 32305626›Full record

ReviewJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2020

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends.

Agnieszka Ścibior, Łukasz Pietrzyk, Zbigniew Plewa, Andrzej Skiba

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07012915 (Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis), which is not on this map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07012915 narecruitingnot on this mapstarted 2025, after this paper: background citation

Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis

TypeinterventionalSponsorWroclaw Medical UniversityRan2025 to 2026Enrolled100ConditionsPeri-ImplantitisArmsBlood testing
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 224 citations in OpenAlex.

  1. Article
  2. Vanadium(IV)-chlorodipicolinate alleviates hepatic steatosis via the AMPK/PGC-1α/CPT1a axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Agnieszka ŚcibiorLaboratory of Oxidative Stress, Centre for Interdisciplinary Research, The John Paull II Catholic University of Lublin, Poland.
Łukasz PietrzykLaboratory of Oxidative Stress, Centre for Interdisciplinary Research, The John Paull II Catholic University of Lublin, Poland.
Zbigniew PlewaDepartment of General, Oncological, and Minimally Invasive Surgery, 1 Military Clinical Hospital with the Outpatient Clinic in Lublin, Poland.
Andrzej SkibaMilitary Clinical Hospital with the Outpatient Clinic in Lublin, Poland.
1 Military Clinical Hospital with Outpatient Clinic · PLJohn Paul II Catholic University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVanadium (V) is an element with a wide range of effects on the mammalian organism. The ability of this metal to form organometallic compounds has contributed to the increase in the number of studies on the multidirectional biological activity of its various organic complexes in view of their application in medicine.

objectiveThis review aims at summarizing the current state of knowledge of the pharmacological potential of V and the mechanisms underlying its anti-viral, anti-bacterial, anti-parasitic, anti-fungal, anti-cancer, anti-diabetic, anti-hypercholesterolemic, cardioprotective, and neuroprotective activity as well as the mechanisms of appetite regulation related to the possibility of using this element in the treatment of obesity. The toxicological potential of V and the mechanisms of its toxic action, which have not been sufficiently recognized yet, as well as key information about the essentiality of this metal, its physiological role, and metabolism with certain aspects on the timeline is collected as well. The report also aims to review the use of V in the implantology and industrial sectors emphasizing the human health hazard as well as collect data on the directions of further research on V and its interactions with Mg along with their character. RESULTS AND

conclusionsMultidirectional studies on V have shown that further analyses are still required for this element to be used as a metallodrug in the fight against certain life-threatening diseases. Studies on interactions of V with Mg, which showed that both elements are able to modulate the response in an interactive manner are needed as well, as the results of such investigations may help not only in recognizing new markers of V toxicity and clarify the underlying interactive mechanism between them, thus improving the medical application of the metals against modern-age diseases, but also they may help in development of principles of effective protection of humans against environmental/occupational V exposure.

Indexed as

AnimalsAnticholesteremic AgentsAnti-Infective AgentsAntineoplastic AgentsCardiotonic AgentsHumansHypoglycemic AgentsNeuroprotective AgentsOrganometallic CompoundsVanadiumAnticholesteremic AgentsAnti-Infective AgentsAntineoplastic AgentsCardiotonic AgentsHypoglycemic AgentsNeuroprotective AgentsOrganometallic CompoundsVanadium3-HMG-CoA, 3-hydroxy-3-methyl-glutaryl-CoAAIDS, acquired immune deficiency syndromeAkt, protein kinase B (PKB)ALB, albuminALP, alkaline phosphataseAmD, Assoc American Dietetic AssociationAnti-B, anti-bacterialAnti-C, anti-cancerAnti-D, anti-diabeticAnti-F, anti-fungalAnti−HC, anti-hypercholesterolemicAnti-O, anti-obesityAnti-P, anti-parasiticAnti-V, anti-viralApoA-I, apolipoprotein AApoB, apolipoprotein BAS, antioxidant statusB, boneBCOV, bis(curcumino)oxavanadylBEOV, bis(ethylmaltolato)oxovanadiumBim, Blc-2 interacting mediator of cell deathBiological roleBMOV, bis(maltolato)oxavanadium(IV)breakD, breakdownBrOP, bromoperoxidaseCardio-P, cardioprotectiveC, cholesterolCD4, CD4 receptorC/EBPα, CCAAT-enhancer-binding protein αCH, cerebral hemisphereCHO-K1, Chinese hamster ovary cellsCitrate-T, citrate transporterCoA, coenzyme ACXCR-4, CXCR-4 chemokine co-receptorCyt c, cytochrome cDM, diabetes mellitusELI, extra low interstitialeNOS, endothelial nitric oxide synthaseERK, extracellular regulated kinaseFasL, Fas ligand, FER: ferritinFHR, fructose hypertensive ratsFKHR/FKHR1/AFX, class O members of the forkhead transcription factor familyFLIP, FLICE-inhibitory proteinFOXOs, forkhead box class O family member proteinsFPP, farnesyl-pyrophosphateGI, gastrointestinalGLU, glucoseGLUT-4, glucose transporter type 4GPP, geranyl-pyrophosphateGPT, glutamate-pyruvate transaminaseGR, glutathione reductaseGSH, reduced glutathioneGSSG, disulfide glutathioneHbF, hemoglobin fractionHb, hemoglobinHDL-C, HDL cholesterolHDL, high-density lipoproteinsHIV, human immunodeficiency virusHMMF, high molecular mass fractionHOMA-IR, insulin resistance indexHyper-LEP, hyperleptynemiaIDDM, insulin-dependent diabetes mellitusIGF-IR, insulin-like growth factor receptorIgG, immunoglobulin GIL, interleukinIndustrial importanceINS, insulinINS-R, insulin resistanceINS-S, insulin sensitivityInteractionsIPP, isopentenyl-5-pyrophosphateIRS, insulin receptor tyrosine kinase substrateJAK2, Janus kinase 2K, kidneyL-AA, L-ascorbic acidLactate-T, lactate transporterLDL-C, LDL cholesterolLDL, low-density lipoproteinsLEP, leptinLEP-R, leptin resistanceLEP-S, leptin sensitivityLEPS, the concentration of leptin in the serumL, liverLMMF, low molecular mass fractionLPL, lipoprotein lipaseLPO, lipid peroxidationMEK, ERK kinase activatorM, mitochondrionmo, monthsMRC, mitochondrial respiratory chainNAC, N-acetylcysteineNaVO3, sodium metavanadateNEP, neutral endopeptidaseNeuro-P, neuroprotectiven-HA, nano-hydroxyapatiteNIDDM, noninsulin-dependent diabetes mellitusNO, nitric oxideNPY, neuropeptide YOrganic-AT, organic anion transporterOver-W, over-weightOXPHOS, oxidative phosphorylationPANC-1, pancreatic ductal adenocarcinoma cellsPARP, poly (ADP-ribose) polymerasePharmacological activityPi3K, phosphoinositide 3-kinase (phosphatidylinositol 3-kinase)PLGA, (Poly)Lactide-co-Glycolide copolymerPO43−, phosphate ionPPARγ, peroxisome-activated receptor γP, plasmapRb, retinoblastoma proteinPTK, tyrosine protein kinasePTP-1B, protein tyrosine phosphatase 1BPTP, protein tyrosine phosphataseRBC, erythrocytesROS, reactive oxygen speciesRT, reverse transcriptaseSAcP, acid phosphatase secreted by LeshmaniaSa, mean roughnessSARS, severe acute respiratory syndromeSC-Ti-6Al-4V, surface-coated Ti-6Al-4VSHR, spontaneously hypertensive ratsSOD, superoxide dismutaseSq, root mean square roughnessSTAT3, signal transducer/activator of transcription 3Sz, ten-point heightTC, total cholesterolTfF, transferrin fractionTf, transferrinTG, triglyceridesTiO2, nHA:Ag-Ti-6Al-4V: titanium oxide-based coating containing hydroxyapatite nanoparticle and silver particlesTop-IB, IB type topoisomeraseToxicological potentialTS, transferrin saturationV5+/V4+, pentavalent/tetravalent vanadiumVanadiumV-BrPO, vanadium bromoperoxidaseV-DLC, diamond-like layer with vanadiumVO2+-FER, vanadyl-ferritin complexVO2+, vanadyl cationVO43-, vanadate ionVO4-/VO3-, vanadate anionVS, vanadyl sulfateV, vanadiumWB, whole bloodwk, weeksZDF rats, Zucker diabetic fatty ratsZF rats, Zucker fatty rats

Identifiers

PMID32305626
PMCPMC7152879
OpenAlexW3015802728

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.