ArticleJACC. Cardiovascular imaging2021
Substrate for the Myocardial Inflammation-Heart Failure Hypothesis Identified Using Novel USPIO Methodology.
Article in JACC. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Nanoparticle-Based Targeted Drug-Delivery Systems for Cardiomyopathy: Mechanisms and Therapeutic Advances.Molecules (Basel, Switzerland) · 2026Review
- Immunometabolism in heart failure.Nature reviews. Cardiology · 2025Review
- Factors Affecting the Quality of Non-contrast Coronary Magnetic Resonance Angiography Images: Challenges and Change.Reviews in cardiovascular medicine · 2025Review
- Magnetic Resonance Imaging in the Evaluation of the Stress System in Acute and Chronic Cardiac Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Intravenous iron therapy results in rapid and sustained rise in myocardial iron content through a novel pathway.European heart journal · 2024Observational
- Targeting Mitochondrial Metabolism to Save the Failing Heart.Life (Basel, Switzerland) · 2023Review
- Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis.Cardiovascular research · 2023Article
- Article
- Role of inflammation in diabetic cardiomyopathy.Therapeutic advances in endocrinology and metabolism · 2022Review
- Role of Cardiovascular Magnetic Resonance to Assess Cardiovascular Inflammation.Frontiers in cardiovascular medicine · 2022Review
- The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases.International journal of molecular sciences · 2021Review
- Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway.Bioengineered · 2021Article
- Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques.BMC medical imaging · 2021Review
- Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure.JACC. Cardiovascular imaging · 2021Article
- Severe T-System Remodeling in Pediatric Viral Myocarditis.Frontiers in cardiovascular medicine · 2020Article
- Cardiac Sarcoidosis: A Contemporary Concept of Forgotten Granulomatosis.ARYA atherosclerosisReview
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20 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesThe purpose of this study was to identify where ultrasmall superparamagnetic particles of iron oxide (USPIO) locate to in myocardium, develop a methodology that differentiates active macrophage uptake of USPIO from passive tissue distribution; and investigate myocardial inflammation in cardiovascular diseases.
backgroundMyocardial inflammation is hypothesized to be a key pathophysiological mechanism of heart failure (HF), but human evidence is limited, partly because evaluation is challenging. USPIO-magnetic resonance imaging (MRI) potentially allows specific identification of myocardial inflammation but it remains unclear what the USPIO-MRI signal represents.
methodsHistological validation was performed using a murine acute myocardial infarction (MI) model. A multiparametric, multi-time-point MRI methodology was developed, which was applied in patients with acute MI (n = 12), chronic ischemic cardiomyopathy (n = 7), myocarditis (n = 6), dilated cardiomyopathy (n = 5), and chronic sarcoidosis (n = 5).
resultsUSPIO were identified in myocardial macrophages and myocardial interstitium. R1 time-course reflected passive interstitial distribution whereas multi-time-point R2* was also sensitive to active macrophage uptake. R2*/R1 ratio provided a quantitative measurement of myocardial macrophage infiltration. R2* behavior and R2*/R1 ratio were higher in infarcted (p = 0.001) and remote (p = 0.033) myocardium in acute MI and in chronic ischemic cardiomyopathy (infarct: p = 0.008; remote p = 0.010), and were borderline higher in DCM (p = 0.096), in comparison to healthy controls, but were no different in myocarditis or sarcoidosis. An R2*/R1 threshold of 25 had a sensitivity and specificity of 90% and 83%, respectively, for detecting active USPIO uptake.
conclusionsUSPIO are phagocytized by cardiac macrophages but are also passively present in myocardial interstitium. A multiparametric multi-time-point MRI methodology specifically identifies active myocardial macrophage infiltration. Persistent active macrophage infiltration is present in infarcted and remote myocardium in chronic ischemic cardiomyopathy, providing a substrate for HF.
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