ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 73 citations in OpenAlex.
- Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study.BMC medicine · 2026Article
- Prenatal maternal psychological distress is associated with neurodevelopmental outcomes in toddlers with congenital heart disease.Pediatric research · 2026Article
- Early functional organization of the anterior and posterior hippocampus in the fetal brain.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Pre- and postnatal maternal depressive symptoms associated with local connectivity of the left amygdala in 5-year-olds.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- COVID-19 Pandemic-Related Prenatal Distress and Infant Functional Brain Development.JAACAP open · 2025Article
- Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring.JAMA network open · 2025Article
- Prenatal Household Income Instability and Infant Subcortical Brain Volumes.Developmental science · 2025Article
- Early life stress impairs hippocampal subfield myelination.Communications biology · 2025Article
- Perinatal Imaging in Partnership with Families (PIPKIN): Longitudinal cohort study protocol.PloS one · 2025Article
- Prenatal Stress and Maternal Role in Neurodevelopment.Annual review of developmental psychology · 2024Article
- Advances in fetal and neonatal neuroimaging and everyday exposures.Pediatric research · 2024Review
- Measuring Socioeconomic and Stress Disparities in Infant Declarative Memory Using the Visual Paired Comparison Task.Developmental psychobiology · 2024Article
- Intergenerational effects of racism on amygdala and hippocampus resting state functional connectivity.Scientific reports · 2024Article
- Prenatal stress and gestational epigenetic age: No evidence of associations based on a large prospective multi-cohort study.Research square · 2024Article
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure.Archives of toxicology · 2024Review
- Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex- and age-based differences in fetal and early childhood hippocampus maturation: a cross-sectional and longitudinal analysis.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring.Cellular and molecular life sciences : CMLS · 2024Article
- The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Prenatal maternal distress-an umbrella concept encompassing multiple negative psychological states including stress, anxiety, and depression-is a substantial prenatal exposure. Consistent across preclinical and human studies, the hippocampus displays alterations due to prenatal distress. Nevertheless, most prenatal distress studies do not focus on multiple dimensions of, have not examined hippocampal functional connectivity in association with, and do not consider observer-based functional outcomes related to distress. We investigated the effects of different dimensions of prenatal distress in pregnant adolescents, a population at high risk for distress, in association with neonatal hippocampal connectivity and infant memory. In pregnant adolescents (n = 42), we collected four measures of distress (perceived stress, depression, pregnancy-specific distress, and 24-h ambulatory salivary cortisol) during the 2nd and 3rd trimesters. Resting-state imaging data were acquired in their infants at 40-44 weeks post-menstrual age. Functional connectivity was measured from hippocampal seeds. Memory abilities were obtained at 4 months using the mobile conjugate reinforcement task. Shared across different dimensions of maternal distress, increased 3rd trimester maternal distress associated with weaker hippocampal-cingulate cortex connectivity and stronger hippocampal-temporal lobe connectivity. Perceived stress inversely correlated while hippocampal-cingulate cortex connectivity positively correlated with infant memory. Increased cortisol-collected during the 2nd, but not the 3rd, trimester-associated with weaker hippocampal-cingulate cortex connectivity and stronger hippocampal-temporal lobe connectivity. Different dimensions of prenatal maternal distress likely contribute shared and unique effects to shaping infant brain and behavior.
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