Evidence map›Paper›PMID 32305025›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2020

Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19.

Xiao-Ying Xia, Jing Wu, He-Lei Liu, Hong Xia, Bei Jia, Wen-Xiang Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 11 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 11 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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  4. The role of asymptomatic and pre-symptomatic infection in SARS-CoV-2 transmission-a living systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xiao-Ying XiaInfectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.
Jing WuInfectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.
He-Lei LiuInfectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.
Hong XiaInfectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.
Bei JiaKey Laboratory of Infectious and Parasitic Diseases in Chongqing, Infectious Disease Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 202253@hospital.cqmu.edu.cn.
Wen-Xiang HuangKey Laboratory of Infectious and Parasitic Diseases in Chongqing, Infectious Disease Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Chongqing Dazu District People's Hospital · CNChongqing Medical University · CNFirst Affiliated Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince December 2019, a new outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan (Hubei, China) and rapidly spread throughout China, however, confirmed cases are still increasing worldwide.

objectivesTo investigate the epidemiological history and initial clinical characteristics of 10 patients with family aggregation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Western Chongqing, China. STUDY

designTen patients positive for SARS-CoV-2 nucleic acid detection by real time Reverse Transcription-Polymerase Chain Reaction (RT-PCR), were collected from The People's Hospital of Dazu District, Chongqing. Epidemiological data and laboratory and imaging results were collected on the first day of admission, and analyzed based on the Diagnosis and Treatment Guideline for COVID-19 (5th edition, China).

resultsOf the 10 cases, case A had a history of a temporary stay in Wuhan and transmitted the virus to the others through family gathering, living together, and sharing vehicles. The average age was 56.5 years (± 11.16), six patients were males, and the incubation period was 2-14 days. Dry cough was the main symptom, followed by fever and fatigue. Most patients were clinically classified as ordinary-type, with three cases being severe-type. Chest computed tomography results were nonspecific, mainly with ground-glass attenuation and/or shadow images. Extensive lesion distribution was seen in severe cases. CD4+ lymphocyte counts were 61, 180, and 348 cells/uL in severe-type patients, respectively. Notably, viral nucleic acid values in nasopharyngeal swabs were lower (19, 25, and 26) than those of ordinary-type patients, suggesting a higher viral load. Neutrophil-lymphocyte ratio (NLR) was also higher in severe-type patients

conclusionsInitial examination results of lower CD4+ lymphocyte counts and RT-PCR-CT values coupled with higher NLR may indicate the severity of COVID-19 infection for these family clusters.

Indexed as

Family HealthAgedBetacoronavirusCD4 Lymphocyte CountChinaCoronavirus InfectionsCoughCOVID-19FemaleFeverHospitalizationHumansMaleMiddle AgedNeutrophilsPandemicsCD4+ countsCOVID-19family aggregationNeutrophil-lymphocyte ratioRT-PCR-CT values

Identifiers

PMID32305025
PMCPMC7151291
OpenAlexW3015233687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.