Evidence map›Paper›PMID 32304844›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020

Evidence for normal intracortical inhibitory recruitment properties in cervical dystonia.

Rebekah L S Summers, Mo Chen, Colum D MacKinnon, Teresa J Kimberley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebekah L S SummersDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota, 426 Church St. SE, Minneapolis, MN 55455, USA; Department of Neurology, School of Medicine, University of Minnesota, 717 Delaware St. SE, Minneapolis, MN 55414, USA. Electronic address: Schm2203@umn.edu.
Mo ChenDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota, 426 Church St. SE, Minneapolis, MN 55455, USA; Non-invasive Neuromodulation Laboratory, MnDRIVE Initiative, University of Minnesota, 247, 717 Delaware St. SE, Minneapolis, MN 55414, USA.
Colum D MacKinnonDepartment of Neurology, School of Medicine, University of Minnesota, 717 Delaware St. SE, Minneapolis, MN 55414, USA.
Teresa J KimberleyDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota, 426 Church St. SE, Minneapolis, MN 55455, USA; School of Health and Rehabilitation Sciences, Department of Physical Therapy, Massachusetts General Hospital, Institute of Health Professions, 36 First Ave, Boston, MA 02129, USA.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NRSA Training CoreTL1TR002493 · NCATS · UNIVERSITY OF MINNESOTA · PI FULKERSON, JAYNE ALLYN · 2018 to 2022
$3.1M
NCATS NIH HHS TL1 TR002493NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR002494
6 · The paper itself

Abstract

objectiveDystonia is associated with reduced intracortical inhibition as measured by the cortical silent period (cSP); however, this may be due to abnormal cSP threshold or input-output properties. This study evaluated cSP recruitment properties in people with cervical dystonia (CD).

methodsBilateral electromyographic recordings were collected in the upper trapezius muscle in response to transcranial magnetic stimulation of the left and right primary motor cortex in a group with CD (n = 19) and controls (n = 21). cSP threshold, cSP input-output properties at stimulation intensities from 1 to 1.4x the cSP threshold, ipsilateral silent period duration (iSP) and timing and magnitude of the contralateral and ipsilateral motor evoked potential (MEP) were assessed.

resultsThe cSP threshold, input-output properties, and contralateral MEP magnitude were not significantly different between groups (all p > 0.07). Hemispheric symmetry was present in the control group while the CD group had reduced iSP (p < 0.01) and a trend for reduced ipsilateral MEP response (p = 0.053) in the left hemisphere.

conclusionsRecruitment properties of intracortical inhibition are similar between control and CD groups. Transcallosal inhibition is asymmetric between hemispheres in people with CD. SIGNIFICANCE: Evidence of normal intracortical inhibition recruitment properties challenge the commonly held view that cortical inhibition is reduced in dystonia.

Indexed as

AdultCerebral CortexElectroencephalographyElectromyographyEvoked Potentials, MotorFemaleHumansMaleMiddle AgedMotor CortexNeural InhibitionSuperficial Back MusclesTorticollisTranscranial Magnetic StimulationCortical excitabilityCortical silent periodDystoniaMotor evoked potentialTranscallosal inhibitionTranscranial magnetic stimulation

Identifiers

PMID32304844
PMCPMC7198360
OpenAlexW3014334150

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.