Evidence map›Paper›PMID 32304770›Full record

ArticleBiochimie2020

Effects of folic acid withdrawal on transcriptomic profiles in murine triple-negative breast cancer cell lines.

Dieuwertje E Kok, Ciara H O'Flanagan, Michael F Coleman, Zahra Ashkavand, Stephen D Hursting, Sergey A Krupenko

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Dieuwertje E KokDivision of Human Nutrition and Health, Wageningen University & Research, the Netherlands. Electronic address: dieuwertje.kok@wur.nl.
Ciara H O'FlanaganDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA. Electronic address: oflanach@gmail.com.
Michael F ColemanDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, USA. Electronic address: mcoleman@unc.edu.
Zahra AshkavandNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, USA. Electronic address: ashkavz@amc.edu.
Stephen D HurstingDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA. Electronic address: hursting@email.unc.edu.
Sergey A KrupenkoDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, USA. Electronic address: sergey_krupenko@unc.edu.
University of North Carolina at Chapel Hill · USDavid H. Murdock Research Institute · USWageningen University & Research · NL

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer ChemoresistanceR35CA197627 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HURSTING, STEPHEN D · 2015 to 2021
$6.0M
Regulation of mitochondrial function by folate enzyme ALDH1L2 in health and diseaseR01DK117854 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KRUPENKO, SERGEY A · 2019 to 2023
$2.4M
NCI NIH HHS R35 CA197627NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK117854
6 · The paper itself

Abstract

We have previously shown that withdrawal of folic acid led to metabolic reprogramming and a less aggressive phenotype in a mouse cell model of triple-negative breast cancer (TNBC). Herein, we evaluate the effects of folic acid withdrawal on transcriptomic profiles in these cells. Murine cell lines were originally derived from a pool of spontaneous mammary tumors grown in MMTV-Wnt1 transgenic mice. Based on their differential molecular characteristics and metastatic potential, these cell lines were previously characterized as non-metastatic epithelial (E-Wnt), non-metastatic mesenchymal (M-Wnt) and metastatic mesenchymal (metM-Wnt

Indexed as

TranscriptomeAnimalsCell Line, TumorCulture MediaEpithelial-Mesenchymal TransitionFemaleFolic AcidMiceMice, TransgenicTriple Negative Breast NeoplasmsWnt Signaling PathwayCulture MediaFolic AcidEpithelial-to-mesenchymal transitionFolic acidInterferon signalingMetastasisTranscriptomicsTriple-negative breast cancer

Identifiers

PMID32304770
PMCPMC7858693
OpenAlexW3016688948

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.