ArticleBrain and behavior2020
Protective effect of epigallocatechin-3-gallate against neuroinflammation and anxiety-like behavior in a rat model of myocardial infarction.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Relationship Between Depression and Epigallocatechin Gallate from the Perspective of Gut Microbiota: A Systematic Review.Nutrients · 2025Pooled it
- Pharmacological Mechanisms of Active Constituents from Traditional Chinese Medicine for Vitiligo Treatment.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Thymoquinone controlled obesity and invigorated cognitive and memory performance in rats consuming a high-fat diet via modulating oxidative stress, inflammation and apoptosis.Scientific reports · 2025Article
- Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics.Drug design, development and therapy · 2025Review
- Article
- Recent advances of traditional Chinese medicine against cardiovascular disease: overview and potential mechanisms.Frontiers in endocrinology · 2024Review
- Epigallocatechin gallate prevents cardiomyocytes from pyroptosis through lncRNA MEG3/TAF15/AIM2 axis in myocardial infarction.Chinese medicine · 2023Article
- Long-Term Consumption of Green Tea Can Reduce the Degree of Depression in Postmenopausal Women by Increasing Estradiol.Nutrients · 2023Article
- Considerations for Optimizing Warfighter Psychological Health with a Research-Based Flavonoid Approach: A Review.Nutrients · 2023Review
- Long-Term Supplementation ofNutrients · 2023Article
- Vitiligo and Mental Health: Natural Compounds' Usefulness.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis.International journal of molecular sciences · 2022Review
- Effect of Epigallocatechin-3-gallate on Stress-Induced Depression in a Mouse Model: Role of Interleukin-1β and Brain-Derived Neurotrophic Factor.Neurochemical research · 2022Article
- Sevoflurane induces microRNA-18a to delay rat neurodevelopment via suppression of the RUNX1/Wnt/β-catenin axis.Cell death discovery · 2022Article
- Cerebral derailment after myocardial infarct: mechanisms and effects of the signaling from the ischemic heart to brain.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Epigallocatechin-3-gallate alleviates gestational stress-induced postpartum anxiety and depression-like behaviors in mice by downregulating semaphorin3A and promoting GSK3β phosphorylation in the hippocampus.Frontiers in molecular neuroscience · 2022Article
- Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions.Molecules (Basel, Switzerland) · 2021Review
- Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia-Reperfusion via Adenosine A1 Receptors in Rats.Frontiers in aging neuroscience · 2021Article
- Dietary Flavonoids in p53-Mediated Immune Dysfunctions Linking to Cancer Prevention.Biomedicines · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIndividuals who experience myocardial infarction (MI) often experience anxiety. Green tea has potent antioxidative properties and, epigallocatechin-3-gallate (EGCG), which is a primary component of tea polyphenols, has advantageous effects on anxiety and depression. However, its mechanism of action regarding the inhibition of anxiety-like symptoms after MI remains unclear. This study examined whether EGCG alleviated anxiety-like behavior in MI rats and its possible mechanism. MATERIAL AND
methodsRats were administered a daily gavage of EGCG (50 mg/kg) 7 days before and 14 consecutive days after the MI procedure. The open-field test and light/dark shuttle box were performed to evaluate anxiety-like behavior. Serum and hippocampus interleukin (IL)-6 levels were tested using ELISA. Caspase 3, caspase 8, caspase 9 and bcl-2 messenger RNA levels in the hippocampus were determined using quantitative polymerase chain reaction, and STAT3 protein was detected by Western blot.
resultsResults of the open field test and light/dark shuttle box task demonstrated that the MI procedure induced anxiety-like behavior in the animals, and this impairment was improved by EGCG. Daily EGCG administration significantly decreased the level of IL-6 both in serum and hippocampus after MI. The administration of EGCG also significantly moderated the expression of caspases 3, 8, and 9 mRNA, which was related to apoptosis in the hippocampus. Furthermore, EGCG also downregulated the expression of STAT3, which was related to the activity of IL-6. These results suggest that EGCG alleviated anxiety-like behavior by inhibiting increases in neuroinflammation and apoptosis in the rat hippocampus. In addition, EGCG reversed alterations of IL-6 and STAT3 in the brain to alleviate apoptosis in the hippocampus.
conclusionsThus, EGCG reversed anxiety-like behavior through an anti-inflammation effect to alleviate apoptosis in neurons and may be a useful therapeutic material for anxiety-like behavior after MI.
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