Evidence map›Paper›PMID 32304229›Full record

ArticleThe Journal of pathology2020

FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression.

Jin Zhang, Xiangmudong Kong, Yanhong Zhang, Wenqiang Sun, Jian Wang, Mingyi Chen, Xinbin Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

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  13. p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jin ZhangComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, CA, USA.
Xiangmudong KongComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, CA, USA.
Yanhong ZhangComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, CA, USA.
Wenqiang SunComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, CA, USA.
Jian WangSchool of Medicine, Wayne State University, Detroit, MI, USA.ORCID 0000-0003-4503-5058
Mingyi ChenDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xinbin ChenComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, CA, USA.ORCID 0000-0002-4582-6506
University of California, Davis · USThe University of Texas Southwestern Medical Center · USWayne State University · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
MECHANISM OF P73 DEPENDENT TUMOR SUPPRESSIONR01CA081237 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 1999 to 2022
$6.8M
The feedback loop between ferredoxin reductase and the p53 family in tumor suppressionR01CA224433 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2018 to 2022
$2.0M
CCAH Grant 2018-18FNCI NIH HHS CA081237NCI NIH HHS CA224433NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA081237NCI NIH HHS R01 CA224433
6 · The paper itself

Abstract

Ferredoxin reductase (FDXR) is a mitochondrial flavoprotein that initiates electron transport from NADPH to several cytochromes P450 via two electron carriers, ferredoxin 1 (FDX1) and FDX2. FDXR is the sole ferredoxin reductase in humans and plays a critical role in steroidogenesis and biosynthesis of heme and iron-sulfur clusters. However, much less is known about the role of FDXR in cancer. Here, we show that FDXR plays a role in tumorigenesis by modulating expression of the tumor suppressor p73. By using genetically modified mouse models, we recently showed that mice deficient in either Fdxr or Trp73 had a shorter lifespan and were prone to spontaneous tumors as compared with wild-type (WT) mice. Interestingly, compound Trp73

Indexed as

Cell ProliferationCellular SenescenceAnimalsFerredoxin-NADP ReductaseGene Expression Regulation, NeoplasticHCT116 CellsHumansIronIron Regulatory Protein 2Mice, Inbred C57BLMice, KnockoutNeoplasmsRNA, MessengerRNA, NeoplasmRNA StabilitySignal TransductionFerredoxin-NADP ReductaseIREB2 protein, humanIreb2 protein, mouseIronIron Regulatory Protein 2RNA, MessengerRNA, NeoplasmTP73 protein, humanTrp73 protein, mouseTumor Protein p73FDX1FDX2iron metabolismiron response elementmRNA stability

Identifiers

PMID32304229
PMCPMC7748393
OpenAlexW3016280778

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.