ArticleBrain imaging and behavior2020
Functional connectivity dysfunction of insular subdivisions in cognitive impairment after acute mild traumatic brain injury.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Functional Connectivity Changes on Resting-State fMRI after Mild Traumatic Brain Injury: A Systematic Review.AJNR. American journal of neuroradiology · 2024Pooled it
- Brain-based correlates of depression and traumatic brain injury: a systematic review of structural and functional magnetic resonance imaging studies.Frontiers in neuroimaging · 2024Pooled it
- Mild Traumatic Brain Injury Is Associated with Early Anterior Insula Hyperactivation During Appraisal of Fearful Stimuli in Trauma Survivors with Probable Post-Traumatic Stress Disorder.Brain sciences · 2026Article
- Fostering experiential learning of neurocognitive skills in brain injury tele-rehabilitation: bridging gaps in remote training by integrating scenario-based digital experiences with coaching.Frontiers in human neuroscience · 2025Article
- A Graph-Based Statistical Approach to Identifying Functional Connectivity Networks in Patients with Traumatic Brain Injury.Iranian journal of child neurology · 2025Article
- The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Aberrant dynamic functional network connectivity in patients with diffuse axonal injury.Scientific reports · 2024Article
- Aberrant dynamic properties of whole-brain functional connectivity in acute mild traumatic brain injury revealed by hidden Markov models.CNS neuroscience & therapeutics · 2024Article
- Prediction of cognitive outcome after mild traumatic brain injury from acute measures of communication within brain networks.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Deep learning-based multimodality classification of chronic mild traumatic brain injury using resting-state functional MRI and PET imaging.Frontiers in neuroscience · 2023Article
- Investigation of the functional pathogenesis of mild cognitive impairment by localisation-based locus coeruleus resting-state fMRI.Human brain mapping · 2022Article
- Aberrant resting-state interhemispheric functional connectivity in patients with anti-N-methyl-D-aspartate receptor encephalitis.Neuroradiology · 2022Article
- Morphometric changes in the cortex following acute mild traumatic brain injury.Neural regeneration research · 2022Article
- Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders.Biological psychiatry · 2022Review
- Aberrant Static and Dynamic Functional Network Connectivity in Acute Mild Traumatic Brain Injury with Cognitive Impairment.Clinical neuroradiology · 2022Article
- Cerebral blood flow network differences correlated with cognitive impairment in mild traumatic brain injury.Frontiers in neuroscience · 2022Article
- Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury.BioMed research international · 2022Observational
- Identification of chronic mild traumatic brain injury using resting state functional MRI and machine learning techniques.Frontiers in neuroscience · 2022Article
- Automated Classification of Resting-State fMRI ICA Components Using a Deep Siamese Network.Frontiers in neuroscience · 2022Article
- Atypical resting state functional connectivity in mild traumatic brain injury.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis study aimed to investigate the early functional connectivity alterations between insula subdivisions and other cortical regions in patients with acute mild traumatic brain injury (mTBI) and subsequently to explore the relationship between functional connectivity changes of insula subdivisions with other cortical regions and cognitive function.
methodsFifty-three mTBI patients and 37 age-, gender- and education level- matched healthy controls were included in this study. All participants obtained resting state functional magnetic resonance imaging (rs-fMRI) and clinical and neuropsychological evaluations (Montreal cognitive assessment, MoCA) at the acute stage. Functional connectivity alterations of insula subdivisions and correlations with MoCA were further explored by seed-voxel functional connectivity.
resultsCompared with healthy controls, patients with acute mTBI showed significantly decreased functional connectivity between the L-vAI and the left middle temporal gyrus and right superior frontal gyrus and significantly decreased functional connectivity between the R-vAI and the right middle frontal gyrus and right hippocampus. While significantly decreased functional connectivity were observed between the L-dAI and the right superior frontal gyrus. In addition, significantly increased functional connectivity was observed between the R-PI and the left inferior frontal gyrus. Furthermore, the mTBI group demonstrated positive correlations between performances in orientation and insula and middle temporal gyrus and superior frontal gyrus and middle frontal gyrus functional connectivities. Abstraction scores for mTBI patients positively correlated with functional connectivity between insula and middle frontal gyrus.
conclusionsThe present study demonstrated functional connectivity dysfunction of insula subdivisions and correlations between these alterations and cognitive performance, which provide a novel insight into the neurophysiological mechanism of cognitive impairment in patients with mTBI at the acute stage.
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