Evidence map›Paper›PMID 32304004›Full record

ArticleMolecular and cellular biochemistry2020

Taurine attenuates isoproterenol-induced H9c2 cardiomyocytes hypertrophy by improving antioxidative ability and inhibiting calpain-1-mediated apoptosis.

Weiwei Li, Jiancheng Yang, Qiufeng Lyu, Gaofeng Wu, Shumei Lin, Qunhui Yang, Jianmin Hu

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Weiwei LiLiaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, Liaoning, People's Republic of China.
Jiancheng YangLiaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, Liaoning, People's Republic of China.
Qiufeng LyuLiaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, Liaoning, People's Republic of China.
Gaofeng WuLiaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, Liaoning, People's Republic of China.
Shumei LinLiaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, Liaoning, People's Republic of China.
Qunhui YangLiaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, Liaoning, People's Republic of China. yangyifei515@syau.edu.cn.ORCID http://orcid.org/0000-0001-9528-9633
Jianmin HuLiaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, Liaoning, People's Republic of China. Hujianmin59@syau.edu.cn.
Shenyang Agricultural University · CN

Funding

National Natural Science Foundation of China 31502026
6 · The paper itself

Abstract

Pathological cardiac hypertrophy is ultimately accompanied by cardiomyocyte apoptosis. Apoptosis mainly related to calpain-1-mediated apoptotic pathways. Studies had proved that taurine can maintain heart health through antioxidation and antiapoptotic functions, but the effect of taurine on cardiac hypertrophy is still unclear. This study aimed to determine whether taurine could inhibit calpain-1-mediated mitochondria-dependent apoptotic pathways in isoproterenol (ISO)-induced hypertrophic cardiomyocytes. We found that taurine could inhibit the increase in cell surface area and reduce the protein expression levels of the hypertrophic markers atrial natriuretic peptide, brain natriuretic polypeptide, and β-myosin heavy chain. Taurine also reduced ROS, intracellular Ca

Indexed as

AnimalsApoptosisApoptotic Protease-Activating Factor 1Atrial Natriuretic Factorbcl-2-Associated X ProteinCalciumCalcium-Binding ProteinsCalpainCardiomegalyCaspase 3Caspase 9Cell LineCytochromes cIsoproterenolMembrane Potential, MitochondrialMitochondriaApaf1 protein, ratApoptotic Protease-Activating Factor 1Atrial Natriuretic Factorbcl-2-Associated X ProteinBcl2 protein, ratCalciumCalcium-Binding ProteinsCalpaincalpastatinCapn1 protein, ratCasp3 protein, ratCasp9 protein, ratCaspase 3Caspase 9Cytochromes cIsoproterenolNatriuretic Peptide, BrainNatriuretic PeptidesProto-Oncogene Proteins c-bcl-2TaurineVentricular MyosinsAntioxidant abilityApoptosisCalpain-1Isoproterenol-induced cardiac hypertrophyTaurine

Identifiers

PMID32304004
OpenAlexW3017043178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.